Gonadotropin-Releasing Hormone and Its Analogues
1991; Massachusetts Medical Society; Volume: 324; Issue: 2 Linguagem: Inglês
10.1056/nejm199101103240205
ISSN1533-4406
AutoresJane F. Desforges, P. Michael Conn, William F. Crowley,
Tópico(s)Estrogen and related hormone effects
ResumoRESEARCH into the neuroendocrine control of reproduction by gonadotropin-releasing hormone (GnRH) has witnessed a remarkable two decades. From the isolation and chemical characterization of GnRH in 1971 through the awarding of the Nobel Prize to Drs. Serially and Guillemin for these accomplishments shortly thereafter, the translation from basic discovery to clinical usefulness has been swift. Food and Drug Administration approvals of GnRH-agonist analogues for the treatment of prostate cancer, endometriosis, and precocious puberty, as well as the use of natural GnRH to induce ovulation, are examples of the clinical usefulness of these fundamental observations. Numerous clinical therapies designed to stimulate . . .
Referência(s)