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Activity of Amlodipine Against Staphylococcus Aureus : Association with Oxacillin and Mechanism of Action

2023; Future Medicine; Volume: 18; Issue: 8 Linguagem: Inglês

10.2217/fmb-2022-0230

1746-0921

Amanda Dias Barbosa, Lívia Gurgel do Amaral Valente Sá, João BA Neto, Daniel Sampaio Rodrigues, Vitória Pessoa de Farias Cabral, Lara Elloyse Almeida Moreira, Igor Aguiar, Hélcio Silva dos Santos, Bruno C. Cavalcanti, Emmanuel Silva Marinho, Jacilene Silva, Hemerson Iury Ferreira Magalhães, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva,

Antibiotics Pharmacokinetics and Efficacy

Aim: This study was designed to evaluate the in vitro antimicrobial activity of amlodipine against Staphylococcus aureus strains. Materials & methods: The antimicrobial activity of amlodipine was evaluated by the broth microdilution method and its interaction with oxacillin was evaluated by checkerboard assay. The possible mechanism of action was evaluated by flow cytometry and molecular docking techniques. Results: Amlodipine showed activity against S. aureus between 64 and 128 μg/ml, in addition to showing synergism in approximately 58% of the strains used. Amlodipine also showed good activity against forming and mature biofilms. The possible mechanism of action may be attributed to its ability to lead to cell death. Conclusion: Amlodipine has antibacterial activity against S. aureus.