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SUCCOR Nodes: May Sentinel Node Biopsy Determine the Need for Adjuvant Treatment?

2023; Springer Science+Business Media; Volume: 30; Issue: 8 Linguagem: Inglês

10.1245/s10434-023-13529-w

1534-4681

Arantxa Berasaluce Gómez, Nerea Martín‐Calvo, Félix Boria, Nabil Manzour, Enrique Chacón, Nicolò Bizzarri, Luis Chiva, Alejandra Martínez, Alfonso Quesada, Ali Kucukmetin, Alicia Vázquez, Aljoša Mandić, Andrea Casajuana, Andreas Kavallaris, Anna Fagotti, Anna Myriam Perrone, Annamaria Ferrero, Arantxa Lekuona, Arno Uppin, Artem Stepanyan, Benito Chiofalo, Bibiana Morillas, Carmen Tauste, Cláudia Regina Furquim de Andrade, Constantijne H. Mom, Cosima Brucker, Cosmin-Paul Sarac, Daniel Vázquez-Vicente, David Cibula, Denis Querleu, Diego Erasun, Dilyara Kaidarova, Dimitrios Tsolakidis, Dimitros Haidopoulos, Dmytro Golub, Eduard-Aexandru Bonci, Elif Akşahin, Elisabete Gonçalves, Enrique Moratalla, Erbil Karaman, Eva Myriokefalitaki, Fabio Ghezzi, Fabrice Narducci, Fernando Alfageme, Francesco Raspagliesi, Frédéric Goffin, Frédéric Grandjean, Frédéric Guyon, Fuat Demirkiran, Gabriel Fiol, G Chakalova, Gemma Mancebo, George Vorgias, Gerhard Gebauer, Gesine Meili, Ginés Hernández-Cortes, Giorgio Bogani, Gloria Cordeiro, Goran Vujić, Gustavo Mendinhos, Hans Trum, Hélène Bonsang‐Kitzis, Herman Haller, Ignace Vergote, Ignacio Zapardiel, Игор Алулоски, Igor Berlev, Imre Pete, Ioannis Kalogiannidis, Ioannis Kotsopoulos, Iryna Yezhova, Javier Dı́ez, Jean Guillaume Féron, Jens-Peter Scharf, Jogchum Jan Beltman, Jolien Haesen, Jordi Ponce, Jorge Cea, José Ángel Mínguez, José Alenza García, Juan Arévalo‐Serrano, Juan Gilabert–Estellés, Juan Luis Alcázar, Kersti Kukk, Khadra Galaal, Laura Cárdenas, Laurențiu Pirtea, Liliana Mereu, Luigi Pedone Anchora, Lukáš Dostálek, Łukasz Klasa, Maja PakižImre, Manuela Undurraga, Marcin Jędryka, Margarida Bernardino, María Alonso-Espías, María Belén Martín-Salamanca, María Cuadra, Mariana Vide Tavares, Mario Malzoni, Mathias K. Fehr, Mathieu Luyckx, Maximilian Lanner, Meelis Leht, Mehmet Mutlu Meydanlı, Michael R. Mallmann, Mihai Emil Căpîlna, Mikuláš Redecha, Milena Mitrović, Minna M Mäenpää, Miriam Guijarro, Nabil Abdalla, Nana Gomes, Natalia Povolotskaya, Nikola Badzakov, Octavio Arencibia, Özgür Akbayır, Pere Cavallé, Petra L.M. Zusterzeel, Philip Rolland, Pluvio Coronado, Rasiah Bharathan, Reeli Saaron, Rita Sousa, Robert Fruscio, Robert Jach, Ròbert Póka, Rosa Barrachina, Santiago Domingo, Sara Morales, Sedat Akgöl, Sergi Fernández-González, Shamistan Aliyev, Sofía Herrero, Soledad Fidalgo, Sonia Prader, Špela Smrkolj, Stamatios Petousis, S Kovachev, Taner Turan, Tayfun Toptaş, Teresa Castellanos, Teresa Diniz da Costa, Tiermes Marina, Vanna Zanagnolo, Victor S. Martı́n, Virginia González, Vladimír Študent, Vladyslav Sukhin,

Ovarian cancer diagnosis and treatment

Abstract Background The SUCCOR cohort was developed to analyse the overall and disease-free survival at 5 years in women with FIGO 2009 stage IB1 cervical cancer. The aim of this study was to compare the use of adjuvant therapy in these women, depending on the method used to diagnose lymphatic node metastasis. Patients and Methods We used data from the SUCCOR cohort, which collected information from 1049 women with FIGO 2009 stage IB1 cervical cancer who were operated on between January 2013 and December 2014 in Europe. We calculated the adjusted proportion of women who received adjuvant therapy depending on the lymph node diagnosis method and compared disease free and overall survival using Cox proportional-hazards regression models. Inverse probability weighting was used to adjust for baseline potential confounders. Results The adjusted proportion of women who received adjuvant therapy was 33.8% in the sentinel node biopsy + lymphadenectomy (SNB+LA) group and 44.7% in the LA group ( p = 0.02), although the proportion of positive nodal status was similar ( p = 0.30). That difference was greater in women with negative nodal status and positive Sedlis criteria (difference 31.2%, p = 0.01). Here, those who underwent a SNB+LA had an increased risk of relapse [hazard ratio (HR) 2.49, 95% confidence interval (CI) 0.98–6.33, p = 0.056] and risk of death (HR 3.49, 95% CI 1.04–11.7, p = 0.042) compared with those who underwent LA. Conclusions Women in this study were less likely to receive adjuvant therapy if their nodal invasion was determined using SNB+LA compared with LA. These results suggest a lack of therapeutic measures available when a negative result is obtained by SNB+LA, which may have an impact on the risk of recurrence and survival.