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PO-02-146 MULTI-OMICS ANALYSIS REVEALS THE METABOLIC AND POLYGENIC BASIS OF BRUGADA SYNDROME

2023; Elsevier BV; Volume: 20; Issue: 5 Linguagem: Inglês

10.1016/j.hrthm.2023.03.718

1556-3871

Carlo Pappone, Giuseppe Ciconte, Vladimir Espinosa Angarica, Andrea Ghiroldi, Emanuele Micaglio, Pasquale Creo, Adriana Tarantino, Michelle M. Monasky, Marco Piccoli, Flavio Mastrocinque, Sara D’Imperio, Žarko Ćalović, Antonio Boccellino, Federica Cirillo, Lorenzo Menicanti, Fiorenzo Gaïta, Gabriele Vicedomini, Vincenzo Santinelli, Enrico Petretto, Luigi Anastasia,

Computational Drug Discovery Methods

Brugada syndrome (BrS) is an inherited disorder that can lead to sudden cardiac death. Candidate genes primarily include those encoding the sodium channel, whereas other genetic variants affecting other channels, signaling, scaffold, sarcomere, and mitochondrial proteins are controversial, leaving the genetic architecture of BrS largely unknown.