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PO-02-177 EPICARDIAL ADIPOSE TISSUE NEUTROPHIL INFLAMMATION RELATES TO SEVERITY BUT NOT TO RECURRENCE OF ATRIAL FIBRILLATION AND IS REFLECTED BY ATTENUATION IN CTA SCANS

2023; Elsevier BV; Volume: 20; Issue: 5 Linguagem: Inglês

10.1016/j.hrthm.2023.03.731

1556-3871

Eva R. Meulendijks, Benedetta Fabrizi, Steffen Bruns, Thomas vd Boogert, Robin Wesselink, Wim Jan van Boven, Antoine H.G. Driessen, Hans W.M. Niessen, Tim A.C. de Vries, Etto C. Eringa, R. Nils Planken, Ivana Išgum, Damini Dey, Sébastien P.J. Krul, Ron A. Hoebe, Joris R. de Groot, Rushd Al‐Shama,

Cardiovascular Disease and Adiposity

Non-invasive tools for personalized, mechanism-based staging of the atrial fibrillation (AF) substrate are immature. Inflammation of the epicardial adipose tissue (EAT) is associated with increased atrial fibrosis in patients with AF. Inflammation correlates with attenuation on CT scans, interpreted as tissue density. However, how CT-EAT attenuation is associated with clinical AF severity, AF recurrence after ablation, and histological (local) inflammatory parameters, is largely unknown.