Portal de Periódicos da CAPES

Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients

2023; Elsevier BV; Volume: 4; Issue: 6 Linguagem: Inglês

10.1016/j.xcrm.2023.101079

2666-3791

Joann Diray‐Arce, Slim Fourati, Naresh Doni Jayavelu, Ravi K. Patel, Cole Maguire, Ana C. Chang, Ravi Dandekar, Jingjing Qi, Brian H. Lee, Patrick van Zalm, Andrew Schroeder, Ernie Chen, Anna Konstorum, Anderson F. Brito, Jeremy P. Gygi, Alvin T. Kho, Jing Chen, Shrikant Pawar, Ana S. González-Reiche, Annmarie Hoch, Carly E. Milliren, James A. Overton, Kerstin Westendorf, Charles B. Cairns, Nadine Rouphael, Steven E. Bosinger, Seunghee Kim‐Schulze, Florian Krammer, Lindsey B. Rosen, Nathan D. Grubaugh, Harm van Bakel, Michael R. Wilson, Jayant V. Rajan, Hanno Steen, Walter L. Eckalbar, Chris Cotsapas, Charles Langelier, Ofer Levy, Matthew C. Altman, Holden T. Maecker, Ruth R. Montgomery, Elias K. Haddad, Rafick‐Pierre Sékaly, Denise Esserman, Al Ozonoff, Patrice M. Becker, Alison D. Augustine, Leying Guan, Bjoern Peters, Steven H. Kleinstein, James Abraham, Michael Adkisson, Albert Marisa, Luz Torres Altamirano, Bonny D. Alvarenga, Matthew L. Anderson, Evan J. Anderson, Azlann Arnett, Hiromitsu Asashima, Mark A. Atkinson, Lindsey R. Baden, Brenda Barton, Katherine Beach, Elizabeth Beagle, Patrice M. Becker, Matthew R. Bell, Mariana Bernui, Christian Bime, Arun K. Boddapati, J. Leland Booth, Brittney Borresen, Scott C. Brakenridge, Laurel Bristow, Robert W. Bryant, Carolyn S. Calfee, Juan Manuel Carreño, Sidney Carrillo, Suzanna Chak, Iris Chang, Jennifer Connors, Michelle Conway, David B. Corry, David Cowan, Brett Croen, Charles S. Dela Cruz, Gina Cusimano, Lily Eaker, Carolyn Pope Edwards, Lauren I. R. Ehrlich, David Elashoff, Heidi L. Erickson, David J. Erle, Shelli Farhadian, Keith Farrugia, Benoit Fatou, Andrea Fernandes, Ana Fernandez‐Sesma, Gabriela K. Fragiadakis, Sara Furukawa, Janelle Geltman, Rajani Ghale, María González, I. Michael Goonewardene, Estella Sanchez Guerrero, Faheem W. Guirgis, David A. Hafler, Sydney Hamilton, Paul G. Harris, Arash Nemati Hayati, Carolyn M. Hendrickson, Nelson Iván Agudelo Higuita, Thomas Hodder, Steven M. Holland, Catherine L. Hough, Christopher Huerta, Kerin Hurley, Scott R. Hutton, Akiko Iwasaki, Alejandra Jáuregui, Meenakshi Jha, Brandi Johnson, David Joyner, Kirsten N. Kangelaris, Geoffrey Kelly, Zain Khalil, Zenab Khan, Farrah Kheradmand, James N. Kim, Hiroki Kimura, Albert I. Ko, Bernard Kohr, Monica Kraft, Matthew F. Krummel, Michele A. Kutzler, Jessica Lasky‐Su, Serena Lee, Deanna Lee, Michael D. Leipold, Claudia Lentucci, Carolyn Leroux, Edward Lin, Shanshan Liu, Christina Love, Zhengchun Lu, Lenka Maliskova, Brittany Roth Manning, Monali Manohar, Mark G. Martens, Grace A. McComsey, Kerry McEnaney, Renee McLin, Esther Melamed, Nataliya Melnyk, Kevin Mendez, William B. Messer, Jordan P. Metcalf, Gregory Michelotti, Eran Mick, Subhasis Mohanty, Jarrod Mosier, Lubbertus C. F. Mulder, Maimouna D. Murphy, Kari R.C. Nadeau, Ebony Nelson, Allison Nelson, Viet Thanh Nguyen, Jordan Oberhaus, Bernadine Panganiban, Kathryn L. Pellegrini, Harry Pickering, Debra Powell, Scott Presnell, Bali Pulendran, Adeeb Rahman, Ahmad Sadeed Rashid, Ariel Raskin, Elaine F. Reed, Susan Pereira Ribeiro, Adreanne M. Rivera, Jacob E. Rogers, Angela J. Rogers, Brandon Rogowski, Rebecca Rooks, Yael Rosenberg‐Hasson, Jessica E. Rothman, Justin F. Rousseau, Ramin Salehi‐Rad, Mehmet Saluvan, Hady Samaha, Joanna Schaenman, Ron Schunk, Nicholas C. Semenza, Subha Sen, Jonathan Sevransky, Vicki Seyfert‐Margolis, Tanzia Shaheen, Albert C. Shaw, Scott F. Sieg, S.A.R. Siegel, Natalia Sigal, Nadia Siles, Brent Simmons, Viviana Simon, Gagandeep Singh, Lauren A. Sinko, Cecilia M. Smith, Kinga K. Smolen, Li-Zhen Song, Komal Srivastava, Peter Sullivan, Caitlin Syphurs, Johnstone Tcheou, George P. Tegos, Greg K. Tharp, Alexandra Tong, Alexandra Tsitsiklis, Ricardo Ungaro, Tatyana Vaysman, Arthur Viodé, Randi Vita, Xiaomei Wang, Alyssa Ward, Dawn C. Ward, Andrew Willmore, Kyra Woloszczuk, Kari E. Wong, Prescott G. Woodruff, Leqi Xu, Simon van Haren, Adriana van de Guchte, Yujiao Zhao,

Long-Term Effects of COVID-19

The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1–3) to more severe disease course (TG4) and death (TG5). Here, we report deep immunophenotyping, profiling of >15,000 longitudinal blood and nasal samples from 540 participants of the IMPACC cohort, using 14 distinct assays. These unbiased analyses identify cellular and molecular signatures present within 72 h of hospital admission that distinguish moderate from severe and fatal COVID-19 disease. Importantly, cellular and molecular states also distinguish participants with more severe disease that recover or stabilize within 28 days from those that progress to fatal outcomes (TG4 vs. TG5). Furthermore, our longitudinal design reveals that these biologic states display distinct temporal patterns associated with clinical outcomes. Characterizing host immune responses in relation to heterogeneity in disease course may inform clinical prognosis and opportunities for intervention.