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Persistent symptoms and risk factors predicting prolonged time to symptom-free after SARS‑CoV‑2 infection: an analysis of the baseline examination of the German COVIDOM/NAPKON-POP cohort

2023; Springer Science+Business Media; Volume: 51; Issue: 6 Linguagem: Inglês

10.1007/s15010-023-02043-6

1439-0973

Yanyan Shi, Ralf Strobl, Christian Apfelbacher, Thomas Bahmer, Ramsia Geisler, Peter U. Heuschmann, Anna Horn, Hanno Hoven, Thomas Keil, Michael Krawczak, Lilian Krist, Christina Lemhöfer, Wolfgang Lieb, Bettina Lorenz‐Depiereux, Rafael Mikolajczyk, Felipe A. Montellano, Jens Peter Reese, Stefan Schreiber, Nicole Skoetz, Stefan Störk, Jörg Janne Vehreschild, Martin Witzenrath, Eva Grill, Maria J. G. T. Vehreschild, Jörg Janne Vehreschild, Hiwa Dashti, Barbara Laumerich, Oliver Pociuli, Nikolaus Büchner, Sabine Adler, Mathias Lehmann, Selçuk Tasci, Maximilian Jorczyk, T. Keller, Michael Schroth, Martin Hower, Lukas Eberwein, Tim Zimmermann, Simon-Dominik Herkenrath, Milena Milovanovic, Ramona Pauli, Jörg Simon, Eckard Hamelmann, Christoph Stellbrink, Johannes-Josef Tebbe, Sven Stieglitz, Christoph Wyen, Jan Bosch, Mirko Steinmüller, Christoph Allerlei, Markus Böbel, Elke Natascha Heinitz, Ariane Roecken, Andrea Münckle-Krimly, Christiane Guderian, Ingmar Silberbaur, H. Schäfer, Claudia Raichle, Christoph D. Spinner, Bernd Schmeck, Heidi Altmann, Nicole Toepfner, Wolfgang Schmidt, Björn‐Erik Ole Jensen, Andreas E. Kremer, Sabine Blaschke, Jochen Dutzmann, Marylyn M. Addo, Robert Bals, Sven Bercker, Phil‐Robin Tepasse, Sandra Frank, Dirk Müller‐Wieland, Anette Friedrichs, Jan Rupp, Siri Göpel, Jens Maschmann, Christine Dhillon, Jacob Nattermann, Ingo Voigt, Wilfred Obst, Martin F. Sprinzl, Christian Scheer, Andreas Teufel, Ulf Günther, Martin Witzenrath, Thomas Keil, Thomas Zöller, Sein Schmidt, Michael Hummel, Lilian Krist, Julia Fricke, Maria Rönnefarth, Denise Treue, Ludie Kretzler, Chantip Dang‐Heine, Paul Triller, Andreas Jooß, Jenny Schlesinger, Natalja Liseweski, Christina Pley, Carmen Scheibenbogen, Marius M. Hoeper, Philipp A. Reuken, Michael von Bergwelt, Rainer Noth, Daniel Drömann, Maria J. G. T. Vehreschild, Siegbert Rieg, István Vadász, Philipp Koehler, Uta Merle, Stefan Schreiber, Peter U. Heuschmann, Stefan Störk, Anette Friedrichs, Astrid Petersmann, Claudia Ellert, Georg Schmidt, Jörg Janne Vehreschild, Katrin Milger, Marie von Lilienfeld, Martin Witzenrath, Oliver Witzke, Patrick Meybohm, Peter U. Heuschmann, Sabine Blaschke, Sandra Frank, Stefan Schreiber, Thomas Hein, Andrea Wittig, Andreas Simm, Anette Friedrichs, Anke Reinacher‐Schick, Anna Frey, Antonella Iannaccone, Astrid Petersmann, Benjamin Maasoumy, Benjamin Waschki, Bimba F. Hoyer, B. van Oorschot, Carolina van Schaik, Christina Lemhöfer, Christina Polidori, Christine Klein, Daniel Medenwald, Eva C. Schulte, Eva Grill, Felix G. Meinel, Folke Brinkmann, Ghazal Arabi, Heike Bickeböller, Holger A. Lindner, Ildikó Gágyor, Jessica C. Hassel, Jürgen Deckert, Katrin Milger, Kerstin U. Ludwig, Marcus Dörr, Marie von Lilienfeld‐Toal, Martin Möckel, Martin Weigl, Matthias Nauck, Miriam Banas, Münevver Demir, Nicole Lindenberg, Nora Hettich, Norma Jung, Oliver Witzke, Orlando Guntinas‐Lichius, Patrick Meybohm, Reinhard Berner, Sabine Blaschke, Samuel Knauß, Sandra Frank, Sebastian E. Baumeister, Sebastian Dolff, Selma Ugurel, Sophia Stöcklein, Stefanie Joos, Winfred Häuser. Jörg Janne Vehreschild, Maximilian Schons, Sina M. Hopff, Markus Brechtel, Cristina Schmidt-Ibanez, Johannes Schneider, Carolin E. M. Jakob, Franziska Voß. Inga Bernemann, Sonja Kunze, Maike Tauchert, Thomas Illig, Gabriele Anton. Cornelia Fiessler, Mirjam Kohls, Olga Miljukov, Steffi Jírů-Hillmann, Jens‐Peter Reese, Peter Reese, Peter U. Heuschmann, Anna‐Lena Hofmann, Julia Schmidt, Kathrin Ungethüm, Anna Horn, Michael Krawczak. Thomas Bahmer, Wolfgang Lieb, Daniel Pape, Stefan Schreiber, Anne Hermes, Irina Lehmann, Corina Maetzler, Lukas Tittmann. Roberto Lorbeer, Bettina Lorenz‐Depiereux, Monika Kraus, Christian Schäfer, J. Schaller, Mario Schattschneider, Dana Stahl, Heike Valentin, Dagmar Krefting, Matthias Nauck. Nicole Toepfner, Reinhard Berner. Christof von Kalle, Sylvia Thun, Alexander Bartschke, Liudmila Lysyakova, Stefanie Rudolph, Julian Sass. Eike Nagel, Valentina O. Püntmann, Tammy Wolf, Thourier Azdad, Franziska Weis, Ira Krückemeier, Simon Bohlender, Deniz Desik, L Laghchioua, Ralf Heyder, Silke Wiedmann,

Multiple Sclerosis Research Studies

We aimed to assess symptoms in patients after SARS-CoV-2 infection and to identify factors predicting prolonged time to symptom-free.COVIDOM/NAPKON-POP is a population-based prospective cohort of adults whose first on-site visits were scheduled ≥ 6 months after a positive SARS-CoV-2 PCR test. Retrospective data including self-reported symptoms and time to symptom-free were collected during the survey before a site visit. In the survival analyses, being symptom-free served as the event and time to be symptom-free as the time variable. Data were visualized with Kaplan-Meier curves, differences were tested with log-rank tests. A stratified Cox proportional hazard model was used to estimate adjusted hazard ratios (aHRs) of predictors, with aHR < 1 indicating a longer time to symptom-free.Of 1175 symptomatic participants included in the present analysis, 636 (54.1%) reported persistent symptoms after 280 days (SD 68) post infection. 25% of participants were free from symptoms after 18 days [quartiles: 14, 21]. Factors associated with prolonged time to symptom-free were age 49-59 years compared to < 49 years (aHR 0.70, 95% CI 0.56-0.87), female sex (aHR 0.78, 95% CI 0.65-0.93), lower educational level (aHR 0.77, 95% CI 0.64-0.93), living with a partner (aHR 0.81, 95% CI 0.66-0.99), low resilience (aHR 0.65, 95% CI 0.47-0.90), steroid treatment (aHR 0.22, 95% CI 0.05-0.90) and no medication (aHR 0.74, 95% CI 0.62-0.89) during acute infection.In the studied population, COVID-19 symptoms had resolved in one-quarter of participants within 18 days, and in 34.5% within 28 days. Over half of the participants reported COVID-19-related symptoms 9 months after infection. Symptom persistence was predominantly determined by participant's characteristics that are difficult to modify.