New insights into the OSBP‒VAP cycle
2023; Elsevier BV; Volume: 82; Linguagem: Inglês
10.1016/j.ceb.2023.102172
ISSN1879-0410
AutoresMélody Subra, Bruno Antonny, Bruno Mesmin,
Tópico(s)Endoplasmic Reticulum Stress and Disease
ResumoVAP-A is a major endoplasmic reticulum (ER) receptor that allows this organelle to engage numerous membrane contact sites with other organelles. One highly studied example is the formation of contact sites through VAP-A interaction with Oxysterol-binding protein (OSBP). This lipid transfer protein transports cholesterol from the ER to the trans-Golgi network owing to the counter-exchange of the phosphoinositide PI(4)P. In this review, we highlight recent studies that advance our understanding of the OSBP cycle and extend the model of lipid exchange to other cellular contexts and other physiological and pathological conditions.
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