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Spatial Immunoprofiling of Adenoid Cystic Carcinoma Reveals B7-H4 Is a Therapeutic Target for Aggressive Tumors

2023; American Association for Cancer Research; Volume: 29; Issue: 16 Linguagem: Inglês

10.1158/1078-0432.ccr-23-0514

ISSN

1557-3265

Autores

Luana Guimarães de Sousa, Daniel J. McGrail, Felippe Lazar Neto, Kaiyi Li, Mario L. Marques‐Piubelli, Sammy Ferri‐Borgogno, Hui Dai, Yoshitsugu Mitani, Nicole Spardy Burr, Zachary A. Cooper, Krista Kinneer, María Angélica Cortez, Shiaw‐Yih Lin, Diana Bell, Adel K. El‐Naggar, Jared K. Burks, Renata Ferrarotto,

Tópico(s)

Nanoplatforms for cancer theranostics

Resumo

Adenoid cystic carcinoma (ACC) is a heterogeneous malignancy, and no effective systemic therapy exists for metastatic disease. We previously described two prognostic ACC molecular subtypes with distinct therapeutic vulnerabilities, ACC-I and ACC-II. In this study, we explored the ACC tumor microenvironment (TME) using RNA-sequencing and spatial biology to identify potential therapeutic targets.

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