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OpenPBTA: The Open Pediatric Brain Tumor Atlas

2023; Elsevier BV; Volume: 3; Issue: 7 Linguagem: Inglês

10.1016/j.xgen.2023.100340

2666-979X

Joshua A. Shapiro, Krutika S. Gaonkar, Stephanie J. Spielman, Candace Savonen, Chanté J. Bethell, Run Jin, Komal S. Rathi, Yuankun Zhu, Laura E. Egolf, Bailey Farrow, Daniel P. Miller, Yang Yang, Tejaswi Koganti, Nighat Noureen, Mateusz Koptyra, Nhat Duong, Mariarita Santi, Jung Kim, Shannon Robins, Phillip B. Storm, Stephen C. Mack, Jena Lilly, Hongbo Xie, Payal Jain, Pichai Raman, Brian R. Rood, Rishi Lulla, Javad Nazarian, Adam Kraya, Zalman Vaksman, Allison P. Heath, Cassie Kline, Laura Scolaro, Angela N. Viaene, Xiaoyan Huang, Gregory P. Way, Steven M. Foltz, Bo Zhang, Anna R. Poetsch, Sabine Mueller, Brian Ennis, Michael D. Prados, Sharon J. Diskin, Siyuan Zheng, Yiran Guo, Shrivats Kannan, Angela J. Waanders, Ashley Margol, Meen Chul Kim, Derek Hanson, Nicholas Van Kuren, Jessica Wong, Rebecca Kaufman, Noel Coleman, Christopher Blackden, Kristina A. Cole, Jennifer Mason, Peter J. Madsen, Carl Koschmann, Douglas R. Stewart, Eric Wafula, Miguel Brown, Adam Resnick, Casey S. Greene, Jo Lynne Rokita, Jaclyn Taroni,

Epigenetics and DNA Methylation

Pediatric brain and spinal cancers are collectively the leading disease-related cause of death in children; thus, we urgently need curative therapeutic strategies for these tumors. To accelerate such discoveries, the Children's Brain Tumor Network (CBTN) and Pacific Pediatric Neuro-Oncology Consortium (PNOC) created a systematic process for tumor biobanking, model generation, and sequencing with immediate access to harmonized data. We leverage these data to establish OpenPBTA, an open collaborative project with over 40 scalable analysis modules that genomically characterize 1,074 pediatric brain tumors. Transcriptomic classification reveals universal