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Retrospective Spatio-Temporal Dynamics of Dengue Virus 1, 2 and 4 in Paraguay

2023; Multidisciplinary Digital Publishing Institute; Volume: 15; Issue: 6 Linguagem: Inglês

10.3390/v15061275

1999-4915

Cynthia Vázquez, Luíz Carlos Júnior Alcântara, Vagner Fonseca, Maurício Lima, Joilson Xavier, Talita Adelino, Hegger Fritsch, Emerson Castro, Carla de Oliveira, Gabriel Schuab, Alex Ranieri Jerônimo Lima, Shirley Villalba, Andrea Gómez de la Fuente, Analia Rojas, César Cantero, Fatima Fleitas, Carolina Aquino, Andrea Ojeda, Guillermo Sequera, Juan Torales, Julio César Quiroz Barrios, Maria Carolina Elias, Felipe Campos de Melo Iani, María José Cilleruelo Ortega, María Liz Gamarra, Romeo Montoya, Evandra Strazza Rodrigues, Simone Kashima, Sandra Coccuzzo Sampaio, Norma Coluchi, Juliana Almeida Leite, Lionel Gresh, Leticia Franco, José Lourenço, Jairo Méndez‐Rico, Ana María Bispo de Filippis, Marta Giovanetti,

Malaria Research and Control

Dengue virus (DENV) has been a major public health concern in Paraguay, with frequent outbreaks occurring since early 1988. Although control measures have been implemented, dengue remains a significant health threat in the country, and continued efforts are required for prevention and control. In response to that, in collaboration with the Central Public Health Laboratory in Asunción, we conducted a portable whole-genome sequencing and phylodynamic analysis to investigate DENV viral strains circulating in Paraguay over the past epidemics. Our genomic surveillance activities revealed the co-circulation of multiple DENV serotypes: DENV-1 genotype V, the emerging DENV-2 genotype III, BR4-L2 clade, and DENV-4 genotype II. Results additionally highlight the possible role of Brazil as a source for the international dispersion of different viral strains to other countries in the Americas emphasizing the need for increased surveillance across the borders, for the early detection and response to outbreaks. This, in turn, emphasizes the critical role of genomic surveillance in monitoring and understanding arbovirus transmission and persistence locally and over long distances.