Evaluation of electroretinography (ERG) parameters as a biomarker for ADHD
2023; Elsevier BV; Volume: 127; Linguagem: Inglês
10.1016/j.pnpbp.2023.110807
ISSN1878-4216
AutoresMarc‐André Dubois, Charles-Antoine Pelletier, Chantal Mérette, Valérie Jomphe, Rose Turgeon, Richard E. Bélanger, Simon Grondin, Marc Hébert,
Tópico(s)Photoreceptor and optogenetics research
ResumoThe retina is recognized as an accessible part of the brain due to their common embryonic origin. The electroretinogram (ERG) has proven to be a valuable tool for detecting schizophrenia and bipolarity. We therefore investigated its ability to detect ADHD.The cone and rod luminance response functions of the ERG were recorded in 26 ADHD subjects (17 women and 9 men) and 25 controls (16 women and 9 men).No significant differences were found between the mixed groups, but sexual dysmorphia was observed in the significant results. In males, a significant prolonged cone a-wave latency was observed in the ADHD group. In females, we observed a significant decrease in the cone a- and b-wave amplitudes and a trend for a prolonged cone b-wave latency as well as a higher scotopic mixed rod-cone a-wave in the ADHD group.The data obtained in this study show the potential of the ERG to detect ADHD, warranting further large-scale studies.
Referência(s)