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Effects of TM6SF2 rs58542926 polymorphism on hepatocellular lipids and insulin resistance in early type 2 diabetes

2023; Elsevier BV; Volume: 33; Issue: 9 Linguagem: Inglês

10.1016/j.numecd.2023.06.004

1590-3729

Kálmán Bódis, Maria Bombrich, Martin Schön, Birgit Knebel, Oana‐Patricia Zaharia, Gidon J. Bönhof, Yanislava Karusheva, Klaus Straßburger, Yuliya Kupriyanova, Jörg Kotzka, Rainer Guthoff, Vera B. Schrauwen‐Hinderling, Hadi Al‐Hasani, Volker Burkart, Julia Szendroedi, Róbert Wágner, Daniel F. Markgraf, Michael Roden,

Metabolism, Diabetes, and Cancer

Background and aims: Increased hepatocellular lipid content (HCL) is linked to insulin resistance, risk of type 2 diabetes and related complications.Conversely, a single-nucleotide polymorphism (TM6SF2 EK ; rs58542926) in the transmembrane 6 superfamily member 2-gene has been associated with nonalcoholic fatty liver disease (NAFLD), but lower cardiovascular risk.This case-control study tested the role of this polymorphism for tissue-specific insulin sensitivity during early course of diabetes.Methods and results: Males with recent-onset type 2 diabetes with (TM6SF2 EK : n Z 16) or without (TM6SF2 EE : n Z 16) the heterozygous TM6SF2-polymorphism of similar age and body mass index, underwent Botnia-clamps with [6,6-2 H 2 ]glucose to measure whole-body-, hepatic-