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Polyketide- and Terpenoid-Derived Metabolites Produced by a Marine-Derived Fungus, Peroneutypa sp.

2023; American Chemical Society; Volume: 86; Issue: 6 Linguagem: Inglês

10.1021/acs.jnatprod.3c00175

1520-6025

Marcelo R. de Amorim, Camila de Souza Barbosa, Tiago Antunes Paz, Laura P. Ióca, Karen de Jesus Nicácio, Lucianne Ferreira Paes de Oliveira, Mirian Oliveira Goulart, Julia M. Paulino, Mateus Oliveira da Cruz, Antônio G. Ferreira, Maysa Furlan, Simone Possedente de Lira, Raquel Alves dos Santos, André Rodrigues, Rafael V. C. Guido, Roberto G. S. Berlinck,

Plant Pathogens and Fungal Diseases

Bioassay-guided investigation of the EtOAc-soluble extract of a culture of the marine-derived fungus Peroneutypa sp. M16 led to the isolation of seven new polyketide- and terpenoid-derived metabolites (1, 2, 4–8), along with known polyketides (3, 9–13). Structures of compounds 1, 2, and 4–8 were established by analysis of spectroscopic data. Absolute configurations of compounds 1, 2, 4, 6, 7, and 8 were determined by the comparison of experimental ECD spectra with calculated CD data. Compound 5 exhibited moderate antiplasmodial activity against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum.