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Ischemic strokes revealing neurosyphilis: Study of six (6) observations at the neurology Department of the University Hospital of Conakry

2023; Elsevier BV; Volume: 32; Linguagem: Inglês

10.1016/j.ensci.2023.100470

2405-6502

M L Touré, Thierno Hamidou Baldé, Mamadou Diallo, Guelngar Carlos Othon, Niels Olsen Saraiva Câmara, Souleymane Barry, Mahadi Moussa Konate, Foksouna Sakadi, Eugene Lamah, Boubacar Diallo, M. Diakité, Adama Moussa Sakho, D. Camara, Santiago Javier Armesilla Conde, Hinami Madandi, V Millimono, A.K.T. Barry, Malik Diallo, Nouhoun Traoré, Francois Dago Kassa, A. Koné, Ibrahima Sory Souaré, J M Kadji, M. Diallo, Adrien Fapeingou Tounkara, S.A. Rafkat, Thierno Diallo, J.F. Mara, F.A. Cissé, A. Cissé,

Syphilis Diagnosis and Treatment

In sub-Saharan Africa (SSA), stroke is a major public health problem and the etiological aspects are poorly studied and documented because of under-medicalization; the syphilitic etiology is rarely mentioned.We performed a retrospective study of 472 patients hospitalized for ischemic stroke between 2016 and 2021 in the Neurology Department of the University Hospital of Conakry, confirmed by neuroradiological explorations (brain CT, MRI-Angio) and a biological workup including VDRL-TPHA serological reactions in blood and CSF.Syphilitic etiology was retained for six (6) patients (4 men and 2 women) with a mean age of 43 years (extremes 36 and 49 years). The clinical picture was dominated by carotid syndromes: superficial and deep sylvian syndrome, anterior cerebral artery syndrome and vertebro-basilar syndromes and one case of lacunar syndrome.The diagnosis was based on the positivity of serological reactions (VDRL-TPHA) in blood and cerebrospinal fluid (CSF) and the presence of a predominantly lymphocytic hypercellularity and a hyperproteinorachy in the CSF in the absence of any other etiology.These neurological vascular syndromes consecutive to a cerebral treponematous attack are often the result of a still poorly conducted management of primary and secondary syphilis in our country.