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New ruthenium( ii ) complexes with cyclic thio- and semicarbazone: evaluation of cytotoxicity and effects on cell migration and apoptosis of lung cancer cells

2023; Royal Society of Chemistry; Volume: 52; Issue: 28 Linguagem: Inglês

10.1039/d3dt00750b

1477-9234

Yasmim G. Gonçalves, Amanda Blanque Becceneri, Angélica E. Graminha, Victor M. Miranda, Rafaella Rebecchi Rios, Francisco Rinaldi‐Neto, Mônica Soares Costa, Ana C.R. Gonçalves, Victor M. Deflon, Kelly Aparecida Geraldo Yoneyama, Pedro I. S. Maia, Eduardo de Faria Franca, Márcia R. Cominetti, Roberto Santana da Silva, Gustavo Von Poelhsitz,

Synthesis and biological activity

We describe the synthesis, physicochemical characterization, and in vitro antitumor assays of four novel analogous ruthenium(II) complexes with general formula cis-[RuII(N-L)(P-P)2]PF6, where P-P = bis(diphenylphosphine)methane (dppm, in complexes 1 and 2) or bis(diphenylphosphine)ethane (dppe, in complexes 3 and 4) and N-L = 5,6-diphenyl-4,5-dihydro-2H-[1,2,4]triazine-3-thione (Btsc, in complexes 1 and 3) or 5,6-diphenyltriazine-3-one (Bsc, in complexes 2 and 4). The data were consistent with cis arrangement of the biphosphine ligands. For the Btsc and Bsc ligands, the data pointed to monoanionic bidentate coordination to ruthenium(II) through N,S and N,O, respectively. Single-crystal X-ray diffraction showed that complex 1 crystallized in the monoclinic system, space group P21/c. Determination of the cytotoxicity profiles of complexes 1-4 gave SI values ranging from 1.19 to 3.50 against the human lung adenocarcinoma cell line A549 and the non-tumor lung cell line MRC-5. Although the molecular docking studies suggested that the interaction between DNA and complex 4 was energetically favorable, the experimental results showed that they interacted weakly. Overall, our results demonstrated that these novel ruthenium(II) complexes have interesting in vitro antitumor potential and this study may contribute to further studies in medicinal inorganic chemistry.