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Hormone Imbalance in Polycystic Ovarian Syndrome

2023; De Gruyter; Volume: 6; Issue: 1 Linguagem: Inglês

10.2478/abmj-2023-0002

2668-5124

Ivan Bergo, David Eckert, Amalia Pușcaș, George Jîtcă, Amelia Tero-Vescan,

Sperm and Testicular Function

Abstract Polycystic Ovarian Syndrome (PCOS) is a disease that is characterized by an increased Gonadotropin-Releasing-Hormone (GnRH) pulsatile frequency, causing an altered LH/FSH ratio. More precisely an increased Luteinizing Hormone (LH) secretion compared to a decreased Follicle-Stimulating Hormone (FSH) secretion leads to the development of hyperandrogenism and to a low-level concentration of estrogens and therefore decreased negative estrogenic feedback in the control axis. The purpose of this review is to connect the physiological Hypothalamic-Pituitary-Ovarian (HPO) axis with said pathology and the ensuring discussion about the possible mechanisms of pathogenesis and guidelines for relieving associated symptoms.