Portal de Periódicos da CAPES

Excretion by subjects on a low (poly)phenol diet of phenolic gut microbiota catabolites sequestered in tissues or associated with catecholamines and surplus amino acids

2023; Taylor & Francis; Volume: 74; Issue: 4 Linguagem: Inglês

10.1080/09637486.2023.2226369

1465-3478

Gema Pereira‐Caro, Salud Cáceres-Jiménez, Letizia Bresciani, Pedro Mena, Tahani Mazyad Almutairi, Sara Dobani, L. Kirsty Pourshahidi, Chris I. R. Gill, José Manuel Moreno‐Rojas, Michael J. Clifford, Alan Crozier,

Tea Polyphenols and Effects

Phenolic catabolites excreted by fasting subjects with a functioning colon and ileostomists on a low (poly)phenol diet have been investigated. Urine was collected over a 12 h fasting period after adherence to a low (poly)phenol diet for 36 h. UHPLC-HR-MS quantified 77 phenolics. Some were present in the urine of both groups in similar trace amounts and others were excreted in higher amounts by participants with a colon indicating the involvement of the microbiota. Most were present in sub- or low-µmol amounts, but hippuric acid dominated accounting on average for 60% of the total for both volunteer categories indicating significant production from sources other than non-nutrient dietary (poly)phenols. The potential origins of the phenolics associated with the low (poly)phenol diet, include endogenous catecholamines, surplus tyrosine and phenylalanine, and washout of catabolites derived from pre-study intakes of non-nutrient dietary (poly)phenols.