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On the causal interpretation of randomised interventional indirect effects

2023; Oxford University Press; Volume: 85; Issue: 4 Linguagem: Inglês

10.1093/jrsssb/qkad066

1467-9868

Caleb H. Miles,

Health Systems, Economic Evaluations, Quality of Life

Abstract Identification of standard mediated effects such as the natural indirect effect relies on heavy causal assumptions. By circumventing such assumptions, so-called randomised interventional indirect effects have gained popularity in the mediation literature. Here, I introduce properties one might demand of an indirect effect measure in order for it to have a true mediational interpretation. For instance, the sharp null criterion requires an indirect effect measure to be null whenever no individual-level indirect effect exists. I show that without stronger assumptions, randomised interventional indirect effects do not satisfy such criteria. I additionally discuss alternative causal interpretations of such effects.