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Chronic Stress Exposure Alters the Gut Barrier: Sex-Specific Effects on Microbiota and Jejunum Tight Junctions

2023; Elsevier BV; Volume: 4; Issue: 1 Linguagem: Inglês

10.1016/j.bpsgos.2023.04.007

2667-1743

Ellen Doney, Laurence Dion‐Albert, François Coulombe-Rozon, Natasha Osborne, Renaud Bernatchez, Sam E.J. Paton, Fernanda Neutzling Kaufmann, Roseline Olory Agomma, José L. Solano, Raphael Gaumond, Katarzyna Dudek, Joanna Kasia Szyszkowicz, Manon Lebel, Alain Doyen, Audrey Durand, Flavie Lavoie‐Cardinal, Marie‐Claude Audet, Caroline Ménard, Frederic Aardema, Lahcen Aït Bentaleb, Janique Beauchamp, Hicham Bendahmane, Élise Benoît, Lise Bergeron, Armando Bertone, Natalie Bertrand, Félix-Antoine Bérubé, Pierre J. Blanchet, Janick Boissonneault, Christine J. Bolduc, Jean‐Pierre Bonin, François Borgeat, Richard Boyer, Chantale Breault, Jean‐Jacques Breton, Catherine Briand, Jacques Brodeur, Krystele Brule, Lyne Brunet, Sylvie Carrière, Carine Chartrand, Rosemarie Chenard-Soucy, Tommy Chevrette, Emmanuelle Cloutier, Richard Cloutier, Hugues J. Cormier, Gilles Côté, Joanne Cyr, Pierre David, Luigi De Benedictis, Marie-Claude Delisle, Patricia Deschenes, Cindy D. Desjardins, Gilbert Desmarais, Jean-Luc Dubreucq, Mimi Dumont, Alexandre Dumais, Guylaine Ethier, Carole Feltrin, Amelie Felx, Helen Findlay, Linda Fortier, Denise Fortin, Leo Fortin, Nathe François, Valérie Gagné, Marie-Pierre Gagnon, Marie-Claude Gignac-Hens, Charles–Édouard Giguère, Roger Godbout, Christine Grou, Stéphane Guay, François Guillem, Najia Hachimi-Idrissi, Christophe L. Herry, Sheilah Hodgins, Saffron Homayoun, Boutheina Jemel, Christian C. Joyal, Édouard Kouassi, Réal Labelle, Denis Lafortune, Michel Lahaie, Souad Lahlafi, Pierre Lalonde, Pierre Landry, V. Lapaige, Guylaine Larocque, C Larue, Marc E. Lavoie, Jean-Jacques Leclerc, Tania Lecomte, Cecile Lecours, Louise E. LeDuc, Marie-France Lelan, André Lemieux, Alain Lachaux, Andree Letarte, J. Y. Lepage, Alain Lévesque, Olivier Lipp, David Luck, Sonia Lupien, Felix-Antoine Lusignan, Richard Lusignan, Andre J. Luyet, Alykhanhthi Lynhiavu, Jean-Pierre Melun, Celine Morin, Luc Nicole, F. Noël, Louise Normandeau, Kieron O’Connor, Christine Ouellette, Veronique Parent, Marie‐Hélène Parizeau, Jean‐François Pelletier, Julie Pelletier, Marc Pelletier, Pierrich Plusquellec, Diane Poirier, Stéphane Potvin, Guylaine Prevost, Marie-Josee Prevost, Pierre Racicot, Marie-France Racine-Gagne, Patrice Renaud, Nicole Ricard, Sylvie Rivet, Michel Rolland, Marc Sasseville, Gabriel Safadi, Sandra L. Smith, Nicole Smolla, Émmanuel Stip, Jakob Teitelbaum, Alfred Thibault, Lucie Thibault, Stephanye Thibault, Frédéric Thomas, Christo Todorov, Valérie Tourjman, Constantin Tranulis, Sonia Trudeau, Gilles Trudel, Nathalie Vacri, Luc Valiquette, Claude Vanier, Kathe Villeneuve, Marie Villeneuve, Philippe Vincent, M.M. Wolfe, Lan Xiong, Angela Zizzi,

Tryptophan and brain disorders

Major depressive disorder (MDD) is the leading cause of disability worldwide. Of individuals with MDD, 30% to 50% are unresponsive to common antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in the microbiota-gut-brain axis has been implicated in MDD pathogenesis. Exposure to chronic stress disrupts blood-brain barrier integrity; still, little is known about intestinal barrier function in these conditions, particularly for the small intestine, where absorption of most foods and drugs takes place.