Vitamin D macro dosing in pregnancy: A case report of D hypervitaminosis in pregnancy according to non-conventional Coimbra protocol and perinatal toxicity
2023; Elsevier BV; Volume: 98; Linguagem: Inglês
10.1016/j.ntt.2023.107221
ISSN1872-9738
AutoresCecilia Lanzi, Andrea Missanelli, Alessandra Ieri, Brunella Occupati, Arianna Totti, Francesco Gambassi, Gilda Belli, Guido Mannaioni, Alessandra Pistelli,
Tópico(s)Bone health and osteoporosis research
ResumoVitamin D is an important prohormone largely derived from sunlight exposure on the skin. In many older people, vitamin D levels have been found to be insufficient or frankly deficient. Alterations in body composition associated with ageing, such as decreased muscle mass and increased adipose tissue, may also decrease vitamin D levels. Low vitamin D levels are associated with an increased risk of falls and fractures and the conditions of frailty and sarcopenia, but confounding with decreased outdoor exposure from a large range of concomitant diseases partly explains these findings. The benefits of vitamin D supplementation found in randomised trials have largely been confined to frail and disabled older people. There is some evidence that bolus vitamin D supplements that achieve supraphysiological levels may increase the risk of falls.
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