Acid-base buffering whether quantified as [H + ] vs. P co 2 or [H + ] vs. strong ion difference is both intuitive and consistent
2023; American Physiological Society; Volume: 135; Issue: 5 Linguagem: Inglês
10.1152/japplphysiol.00276.2023
ISSN8750-7587
Autores Tópico(s)Sepsis Diagnosis and Treatment
ResumoViewpointAcid-base buffering whether quantified as [H+] vs. Pco2 or [H+] vs. strong ion difference is both intuitive and consistentMatthew B. WolfMatthew B. WolfDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina, Columbia, South Carolina, United StatesPublished Online:16 Nov 2023https://doi.org/10.1152/japplphysiol.00276.2023This is the final version - click for previous versionMoreSectionsFull TextPDF (452 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat REFERENCES1. Giosa L, Zadek F, Langer T. The buffer power of blood: a reappraisal of its mathematical expressions with implications on the role of albumin as a buffer. J Appl Physiol (1985) 135: 196–199, 2023. doi:10.1152/japplphysiol.00083.2023. Link | ISI | Google Scholar2. Wolf MB. Physicochemical properties of abnormal blood acid-base buffering. J Appl Physiol (1985) 134: 172–180, 2023. doi:10.1152/japplphysiol.00309.2022. Link | ISI | Google Scholar3. Langer T, Brusatori S, Carlesso E, Zadek F, Brambilla P, Ferraris Fusarini C, Duska F, Caironi P, Gattinoni L, Fasano M, Lualdi M, Alberio T, Zanella A, Pesenti A, Grasselli G. Low noncarbonic buffer power amplifies acute respiratory acid-base disorders in patients with sepsis: an in vitro study. J Appl Physiol (1985) 131: 464–473, 2021. doi:10.1152/japplphysiol.00787.2020. Link | ISI | Google Scholar4. Van Slyke DD. On the measurement of buffer values and on the relationship of buffer value to the dissociation constant of the buffer and the concentration and reaction of the buffer solution. J Biol Chem 52: 525–570, 1922. doi:10.1016/S0021-9258(18)85845-8.Crossref | Google Scholar5. Krbec M, Koudelková K, Duška F. On acid-base effects of albumin. Curr Med Res Opin 37: 1515–1516, 2021. doi:10.1080/03007995.2021.1944074. Crossref | PubMed | ISI | Google Scholar6. Stewart PA. How to Understand Acid-Base: A Quantitative Acid-Base Primer for Biology and Medicine. New York: Elsevier North Holland, 1981.Google Scholar7. Rossing TH, Maffeo N, Fencl V. Acid-base effects of altering plasma protein concentration in whole blood. J Appl Physiol (1985) 61: 2260–2265, 1986. doi:10.1152/jappl.1986.61.6.2260. Link | ISI | Google Scholar Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Related ArticlesAcid-base buffer: H+ load or the supplement rush? 16 Nov 2023Journal of Applied PhysiologyThe albumin, the hydrogen, the carbon dioxide, and the bicarbonate: four substances and a conflict 16 Nov 2023Journal of Applied PhysiologyA small (but interesting) "trans-Atlantic acid-base debate" 16 Nov 2023Journal of Applied PhysiologyMuch ado about albumin: solving the controversy around its buffering properties 16 Nov 2023Journal of Applied PhysiologyLast Word on Viewpoint: Acid-base buffering whether quantified as [H+] vs. Pco2 or [H+] vs. strong ion difference is both intuitive and consistent—the role of albumin and strong-ion difference (SID) in acid-base buffering 16 Nov 2023Journal of Applied PhysiologyCited ByThe albumin, the hydrogen, the carbon dioxide, and the bicarbonate: four substances and a conflictAimée Obolari Durço, Karina Oliveira Mota, Lino Sergio Rocha Conceição, andDiego Santos Souza16 November 2023 | Journal of Applied Physiology, Vol. 135, No. 5Acid-base buffer: H+ load or the supplement rush?Rafael Correa Teodoro, Caroline Santiago dos Santos, Guilherme Pereira Saborosa, Raphael de Oliveira Freitas Dinalli, Francisco de Assis Manoel, andSandro Fernandes da Silva16 November 2023 | Journal of Applied Physiology, Vol. 135, No. 5Much ado about albumin: solving the controversy around its buffering propertiesLorenzo Giosa, andFrancesco Zadek16 November 2023 | Journal of Applied Physiology, Vol. 135, No. 5A small (but interesting) "trans-Atlantic acid-base debate"Thomas Langer, Beatrice Brunoni, andRoberto Fumagalli16 November 2023 | Journal of Applied Physiology, Vol. 135, No. 5Last Word on Viewpoint: Acid-base buffering whether quantified as [H+] vs. Pco2 or [H+] vs. strong ion difference is both intuitive and consistent—the role of albumin and strong-ion difference (SID) in acid-base bufferingMatthew B. Wolf16 November 2023 | Journal of Applied Physiology, Vol. 135, No. 5 More from this issue > Volume 135Issue 5November 2023Pages 1176-1179 Crossmark Copyright & PermissionsCopyright © 2023 the American Physiological Society.https://doi.org/10.1152/japplphysiol.00276.2023PubMed37410903History Received 2 May 2023 Accepted 5 July 2023 Published online 16 November 2023 Published in print 1 November 2023 Keywordsacid-base bufferingcarbon dioxidehydrogen ion concentrationmathematical model Metrics
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