Definition, diagnosis and epidemiology of acute‐on‐chronic liver failure
2023; Wiley; Linguagem: Inglês
10.1111/liv.15670
ISSN1478-3231
AutoresRubén Hernáez, Hai Li, Richard Moreau, Minneke J. Coenraad,
Tópico(s)Drug-Induced Hepatotoxicity and Protection
ResumoAbstract This narrative review addresses the definition of acute‐on‐chronic liver failure, a condition associated with high short‐term mortality in patients with chronic liver disease and/or cirrhosis. We provide two major points of view: the East and the West perspective. Both definitions vary regarding the underlying patient population and organ failure(s) definition. Nevertheless, all the definitions have their clinical utility: from the core concept of having the “liver” as a conditio sine qua non, the syndrome cannot exist (Asian Pacific Association for the Study of the Liver); a data‐driven, robust definition (European Association for the Study of the Liver); a bedside tool that can quickly identify patients at high risk of dying (North American Consortium for the Study of End‐stage Liver Disease [NACSELD]). In each section, we provide the overall definitions, the criteria of organ failure(s), and some epidemiological data illustrating how these apply in each area of the world.
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