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Hypomelanosis of Ito

1977; Soc for Publication of Acta Dermato-Venereologica; Volume: 57; Issue: 3 Linguagem: Inglês

10.2340/0001555557261264

1651-2057

JJ Nordlund, SN Klaus, J. Gino,

melanin and skin pigmentation

Hypomelanosis of Ito appears to be a disorder of hypopigmentation. Findings from histochemical and electronmicroscopic studies indicate that pigment cells from the hypopigmented areas have short dendrites and synthesize less than normal amounts of melanin. The syndrome may have two forms; a cutaneous and neurocutaneous variety. In the more severe neurocutaneous variety, the phenotypic pigmentary abnormalities probably reflect a biochemical defect in all tissues derived from the neuro-ectodermal anlage.