Produção Nacional
Revisado por pares
miRNAs in Neurological Manifestation in Patients Co-Infected with SARS-CoV-2 and Herpesvírus 6 (HHV-6)
2023; Multidisciplinary Digital Publishing Institute; Volume: 24; Issue: 13 Linguagem: Inglês
10.3390/ijms241311201
ISSN1661-6596
AutoresVanessa Cristine de Souza Carneiro, Otacílio C. Moreira, Wagner Luís da Costa Nunes Pimentel Coelho, Beatriz Chan Rio, Dmitry José de Santana Sarmento, Andreza Lemos Salvio, Soniza Vieira Alves‐Leon, Vanessa Salete de Paula, Luciane Almeida Amado Leon,
Tópico(s)Extracellular vesicles in disease
ResumoHuman herpesviruses (HHVs) can establish latency and be reactivated, also are neurotropic viruses that can trigger neurological disorders. HHV-6 is a herpesvirus that is associated with neurological disorders. Studies have reported the detection of HHV-6 in patients with COVID-19 and neurological manifestations. However, specific diagnoses of the neurological disorders caused by these viruses tend to be invasive or difficult to interpret. This study aimed to establish a relationship between miRNA and neurological manifestations in patients co-infected with COVID-19 and HHV-6 and evaluate miRNAs as potential biomarkers. Serum samples from COVID-19 patients in the three cohorts were analyzed. miRNA analysis by real-time polymerase chain reaction (qPCR) revealed miRNAs associated with neuroinflammation were highly expressed in patients with neurological disorders and HHV-6 detection. When compared with the group of patients without detection of HHVs DNA and without neurological alterations, the group with detection of HHV-6 DNA and neurological alteration, displayed significant differences in the expression of mir-21, mir-146a, miR-155 and miR-let-7b (p < 0.01). Our results reinforce the involvement of miRNAs in neurological disorders and provide insights into their use as biomarkers for neurological disorders triggered by HHV-6. Furthermore, understanding the expression of miRNAs may contribute to therapeutic strategies.
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