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Altered placental ion channel gene expression in preeclamptic high-altitude pregnancies

2023; American Physical Society; Volume: 55; Issue: 9 Linguagem: Inglês

10.1152/physiolgenomics.00013.2023

1531-2267

Colleen G. Julian, Julie A. Houck, Sahand Fallahi, Litzi Lazo-Vega, Christopher J. Matarazzo, Breea Diamond, Valquiria Miranda-Garrido, Bernardo J. Krause, Lorna G. Moore, Jonathan Shortt, Lilian Toledo-Jaldin, Ramón A. Lorca,

Heme Oxygenase-1 and Carbon Monoxide

High-altitude (>2,500 m) residence increases the risk of pregnancy vascular disorders such as fetal growth restriction and preeclampsia, each characterized by impaired placental function. Genetic attributes of highland ancestry confer relative protection against vascular disorders of pregnancy at high altitudes. Although ion channels have been implicated in placental function regulation, neither their expression in high-altitude placentas nor their relationship to high-altitude preeclampsia has been determined. Here, we measured the expression of 26 ion-channel genes in placentas from preeclampsia cases and normotensive controls in La Paz, Bolivia (3,850 m). In addition, we correlated gene transcription to maternal and infant ancestry proportions. Gene expression was assessed by PCR, genetic ancestry evaluated by