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Crosstalk of Inflammation and Coagulation in Bothrops Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology

2023; Multidisciplinary Digital Publishing Institute; Volume: 24; Issue: 14 Linguagem: Inglês

10.3390/ijms241411508

1661-6596

Joeliton S. Cavalcante, Denis Emanuel Garcia de Almeida, Norival A. Santos‐Filho, Marco Aurélio Sartim, Amanda de Almeida Baldo, Lisele Brasileiro, Polianna Lemos Moura Moreira Albuquerque, Sâmella Silva de Oliveira, Jacqueline de Almeida Gonçalves Sachett, Wuelton Marcelo Monteiro, Rui Seabra Ferreira,

Rabies epidemiology and control

Snakebite envenoming represents a major health problem in tropical and subtropical countries. Considering the elevated number of accidents and high morbidity and mortality rates, the World Health Organization reclassified this disease to category A of neglected diseases. In Latin America, Bothrops genus snakes are mainly responsible for snakebites in humans, whose pathophysiology is characterized by local and systemic inflammatory and degradative processes, triggering prothrombotic and hemorrhagic events, which lead to various complications, organ damage, tissue loss, amputations, and death. The activation of the multicellular blood system, hemostatic alterations, and activation of the inflammatory response are all well-documented in Bothrops envenomings. However, the interface between inflammation and coagulation is still a neglected issue in the toxinology field. Thromboinflammatory pathways can play a significant role in some of the major complications of snakebite envenoming, such as stroke, venous thromboembolism, and acute kidney injury. In addition to exacerbating inflammation and cell interactions that trigger vaso-occlusion, ischemia–reperfusion processes, and, eventually, organic damage and necrosis. In this review, we discuss the role of inflammatory pathways in modulating coagulation and inducing platelet and leukocyte activation, as well as the inflammatory production mediators and induction of innate immune responses, among other mechanisms that are altered by Bothrops venoms.