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Association of Very Early Treatment Initiation With the Risk of Long-term Disability in Patients With a First Demyelinating Event

2023; Lippincott Williams & Wilkins; Volume: 101; Issue: 13 Linguagem: Inglês

10.1212/wnl.0000000000207664

1526-632X

Álvaro Cobo‐Calvo, Carmen Tur, Susana Otero‐Romero, Pere Carbonell‐Mirabent, Mariano Ruíz, Agustín Pappolla, Javier Villacieros Alvarez, Ángela Vidal‐Jordana, Georgina Arrambide, Joaquín Castilló, Ingrid Galán, Marta Rodríguez Barranco, Luciana Soledad Midaglia, Carlos Nos, Breogán Rodrı́guez‐Acevedo, Ana Zabalza, Neus Mongay‐Ochoa, Jordi Río, Manuel Comabella, Cristina Auger, Jaume Sastre‐Garriga, Àlex Rovira, Mar Tintoré, Xavier Montalbán,

Health Systems, Economic Evaluations, Quality of Life

Early treatment is associated with better long-term outcomes in patients with a first demyelinating event and early multiple sclerosis (MS). However, magnetic resonance (MR) findings are not usually integrated to construct propensity scores (PSs) when evaluating outcomes. We assessed the association of receiving very early treatment with the risk of long-term disability including an MR score (MRS) in patients with a first demyelinating event.