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Age-related pathophysiological alterations in molecular stress markers and key modulators of hypoxia

2023; Elsevier BV; Volume: 90; Linguagem: Inglês

10.1016/j.arr.2023.102022

1872-9649

Pinky Pinky, Neha Neha, Mohd Salman, Pratika Kumar, Mohammad Ahmed Khan, Azfar Jamal, Suhel Parvez,

Neuroinflammation and Neurodegeneration Mechanisms

Alzheimer's disease (AD) is characterized by an adverse cellular environment and pathological alterations in distinct brain regions. The development is triggered or facilitated by a condition such as hypoxia or ischemia, or inflammation and is associated with disruptions of fundamental cellular functions, including metabolic and ion homeostasis. Increasing evidence suggests that hypoxia may affect many pathological aspects of AD, including oxidative stress, mitochondrial dysfunction, ER stress, amyloidogenic processing of APP, and Aβ accumulation, which may collectively result in neurodegeneration. Further investigation into the relationship between hypoxia and AD may provide an avenue for the effective preservation and pharmacological treatment of this neurodegenerative disease. This review summarizes the effects of normoxia and hypoxia on AD pathogenesis and discusses the underlying mechanisms. Regulation of HIF-1α and the role of its key players, including P53, VEGF, and GLUT1, are also discussed.