Stereoselective amino acid synthesis by synergistic photoredox-pyridoxal radical biocatalysis
2023; American Association for the Advancement of Science; Volume: 381; Issue: 6656 Linguagem: Inglês
10.1126/science.adg2420
ISSN1095-9203
AutoresLei Cheng, Dian Li, Binh Khanh, Zhiyu Bo, Lida Cheng, Peng Liu, Yang Yang,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoDeveloping synthetically useful enzymatic reactions that are not known in biochemistry and organic chemistry is an important challenge in biocatalysis. Through the synergistic merger of photoredox catalysis and pyridoxal 5'-phosphate (PLP) biocatalysis, we developed a pyridoxal radical biocatalysis approach to prepare valuable noncanonical amino acids, including those bearing a stereochemical dyad or triad, without the need for protecting groups. Using engineered PLP enzymes, either enantiomeric product could be produced in a biocatalyst-controlled fashion. Synergistic photoredox
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