
Nanoencapsulated all- trans retinoic acid as an adjuvant for mucosal vaccines
2023; Future Medicine; Volume: 18; Issue: 13 Linguagem: Catalão
10.2217/nnm-2023-0144
ISSN1748-6963
AutoresGabriel Silva Marques Borges, Eduardo Burgarelli Lages, Gisele Assis Castro Goulart, Lucas Antônio Miranda Ferreira,
Tópico(s)T-cell and B-cell Immunology
ResumoNanomedicineAhead of Print EditorialNanoencapsulated all-trans retinoic acid as an adjuvant for mucosal vaccinesGabriel SM Borges‡, Eduardo B Lages‡, Gisele AC Goulart & Lucas AM FerreiraGabriel SM Borges‡ *Author for correspondence: Tel.: +55 383 532 1200; E-mail Address: gsmborges@gmail.comhttps://orcid.org/0000-0002-7360-8231Departamento de Farmácia, Faculdade de Ciências Biológicas e da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, CEP 39100-000, Minas Gerais, Brazil, Eduardo B Lages‡ https://orcid.org/0000-0002-2458-6021Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, CEP 31270–901, Minas Gerais, Brazil, Gisele AC Goulart https://orcid.org/0000-0003-0292-076XDepartamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, CEP 31270–901, Minas Gerais, Brazil & Lucas AM Ferreira https://orcid.org/0000-0003-2474-5536Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, CEP 31270–901, Minas Gerais, BrazilPublished Online:28 Jul 2023https://doi.org/10.2217/nnm-2023-0144AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: adjuvantsall-trans retinoic acidnanomedicinetretinoinvaccineReferences1. Imdad A, Mayo-Wilson E, Haykal MR et al. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. Cochrane Database Syst. Rev. 3(3), CD008524 (2022).Medline, Google Scholar2. Hao X, Zhong X, Sun X. The effects of all-trans retinoic acid on immune cells and its formulation design for vaccines. AAPS J. 23(2), 32 (2021).Crossref, Medline, CAS, Google Scholar3. Riccomi A, Piccaro G, Christensen D, Palma C, Andersen P, Vendetti S. Parenteral vaccination with a tuberculosis subunit vaccine in presence of retinoic acid provides early but transient protection to M. tuberculosis infection. Front. Immunol. 10, 934 (2019).Crossref, Medline, CAS, Google Scholar4. Tuyishime S, Haut LH, Zhu C, Ertl HCJ. Enhancement of recombinant adenovirus vaccine-induced primary but not secondary systemic and mucosal immune responses by all-trans retinoic acid. Vaccine 32(27), 3386–3392 (2014).Crossref, Medline, CAS, Google Scholar5. Sinha R, Howlader DR, Ta A, Mitra S, Das S, Koley H. Retinoic acid pre-treatment down regulates V. cholerae outer membrane vesicles induced acute inflammation and enhances mucosal immunity. Vaccine 35(28), 3534–3547 (2017).Crossref, Medline, CAS, Google Scholar6. Lisulo MM, Chomba MS, Chama M et al. Retinoic acid elicits a coordinated expression of gut homing markers on T lymphocytes of Zambian men receiving oral Vivotif, but not Rotarix, Dukoral or OPVERO vaccines. Vaccine 36(28), 4134–4141 (2018).Crossref, Medline, Google Scholar7. Lisulo MM, Kapulu MC, Banda R et al. Adjuvant potential of low dose all-trans retinoic acid during oral typhoid vaccination in Zambian men. Clin. Exp. Immunol. 175(3), 468–475 (2014).Crossref, Medline, CAS, Google Scholar8. Lavelle EC, Ward RW. Mucosal vaccines – fortifying the frontiers. Nat. Rev. Immunol. 22(4), 236–250 (2022).Crossref, Medline, CAS, Google Scholar9. Khalil IA, Troeger C, Blacker BF et al. Morbidity and mortality due to Shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990–2016. Lancet Infect. Dis. 18(11), 1229–1240 (2018).Crossref, Medline, Google Scholar10. Cohen PA, Jhingran A, Oaknin A, Denny L. Cervical cancer. Lancet 393(10167), 169–182 (2019).Crossref, Medline, Google Scholar11. Nakahashi-Ouchida R, Fujihashi K, Kurashima Y, Yuki Y, Kiyono H. Nasal vaccines: solutions for respiratory infectious diseases. Trends Mol. Med. 29(2), 124–140 (2023).Crossref, Medline, Google Scholar12. Borges GSM, Lima FA, Carneiro G, Goulart GAC, Ferreira LAM. All-trans retinoic acid in anticancer therapy: how nanotechnology can enhance its efficacy and resolve its drawbacks. Expert Opin. Drug Deliv. 18(10), 1335–1354 (2021).Crossref, Medline, CAS, Google Scholar13. Lima FA, Vilela RVR, Oréfice RL et al. Nanostructured lipid carriers enhances the safety profile of tretinoin: in vitro and healthy human volunteers' studies. Nanomedicine 16(16), 1391–1409 (2021).Link, CAS, Google Scholar14. Dumpa N, Goel K, Guo Y et al. Stability of vaccines. AAPS PharmSciTech 20(2), 42 (2019).Crossref, Medline, CAS, Google Scholar15. Xia Y, Wu J, Du Y, Miao C, Su Z, Ma G. Bridging systemic immunity with gastrointestinal immune responses via oil-in-polymer capsules. Adv. Mater. 30(31), 1801067 (2018).Crossref, Google Scholar16. Ferreira R, Napoli J, Enver T, Bernardino L, Ferreira L. Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine. Nat. Commun. 11(1), 4265 (2020).Crossref, Medline, CAS, Google Scholar17. Bezerra IPS, Costa-Souza BLS, Carneiro G, Ferreira LAM, Guedes HLM, Rossi-Bergmann B. Nanoencapsulated retinoic acid as a safe tolerogenic adjuvant for intranasal vaccination against cutaneous leishmaniasis. Vaccine 37(28), 3660–3667 (2019).Crossref, Medline, CAS, Google Scholar18. Oliveira MS, Goulart GCA, Ferreira LAM, Carneiro G. Hydrophobic ion pairing as a strategy to improve drug encapsulation into lipid nanocarriers for the cancer treatment. Expert Opin. Drug Deliv. 14(8), 983–995 (2017).Crossref, Medline, CAS, Google Scholar19. Said DE, Amer EI, Sheta E, Makled S, Arafa FM, Diab HE. Nano-encapsulated antioxidant: retinoic acid as a natural mucosal adjuvant for intranasal immunization against chronic experimental toxoplasmosis. Trop. Med. Infect. Dis. 8(2), 106 (2023).Crossref, Medline, Google Scholar20. Christensen D, Bøllehuus Hansen L, Leboux R et al. A liposome-based adjuvant containing two delivery systems with the ability to induce mucosal immunoglobulin A following a parenteral immunization. ACS Nano 13(2), 1116–1126 (2019).Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Ahead of Print STAY CONNECTED Metrics Downloaded 0 times History Received 23 May 2023 Accepted 4 July 2023 Published online 28 July 2023 Information© 2023 Future Medicine LtdKeywordsadjuvantsall-trans retinoic acidnanomedicinetretinoinvaccineFinancial & competing interests disclosureThis work was supported by the Brazilian agencies FAPEMIG (Fundação de Amparo à Pesquisa do Estado de Minas Gerais), CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
Referência(s)