Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Roux-en-Y Gastric Bypass Improves Adiponectin to Leptin Ratio and Inflammatory Profile in Severely Obese Women with and without Metabolic Syndrome: A Randomized Controlled Trial

2023; Multidisciplinary Digital Publishing Institute; Volume: 15; Issue: 15 Linguagem: Inglês

10.3390/nu15153312

2072-6643

Sandra M. B. P. Moreira, André Luís Lacerda Bachi, Elias I. Jirjos, Carlos Alberto Malheiros, Sérgio Vencio, Vera Lúcia dos Santos Alves, Alan Robson Trigueiro de Sousa, Lucenda A. Felipe, Eduardo Araújo Perez, Maria Eduarda Moreira Lino, Shayra Kellen Arantes Souza, Juliana de Melo Batista dos Santos, Miriã Cândida Oliveira, Adriano Luís Fonseca, Carlos H. M. Silva, Rodolfo P. Vieira, Giuseppe Insalaco, Wilson Rodrigues de Freitas, Luís Vicente Franco de Oliveira,

Adipokines, Inflammation, and Metabolic Diseases

Obesity is a troubling public health problem as it increases risks of sleep disorders, respiratory complications, systemic arterial hypertension, cardiovascular diseases, type 2 diabetes mellitus, and metabolic syndrome (MetS). As a measure to counteract comorbidities associated with severe obesity, bariatric surgery stands out. This study aimed to investigate the adiponectin/leptin ratio in women with severe obesity with and without MetS who had undergone Roux-en-Y gastric bypass (RYGB) and to characterize the biochemical, glucose, and inflammatory parameters of blood in women with severe obesity before and after RYGB. Were enrolled females with severe obesity undergoing RYGP with MetS (n = 11) and without (n = 39). Anthropometric data and circulating levels of glucose, total cholesterol, high-density lipoprotein (HDL), non-HDL total cholesterol, low-density lipoprotein (LDL), adiponectin, and leptin were assessed before and 6 months after RYGB. Significant reductions in weight, body mass index, and glucose, total cholesterol, LDL, and leptin were observed after surgery, with higher levels of HDL, adiponectin, and adiponectin/leptin ratio being observed after surgery compared to the preoperative values of those. This study demonstrated that weight loss induced by RYGB in patients with severe obesity with or without MetS improved biochemical and systemic inflammatory parameters, particularly the adiponectin/leptin ratio.