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Plasma Sphingomyelin Disturbances: Unveiling Its Dual Role as a Crucial Immunopathological Factor and a Severity Prognostic Biomarker in COVID-19

2023; Multidisciplinary Digital Publishing Institute; Volume: 12; Issue: 15 Linguagem: Inglês

10.3390/cells12151938

2073-4409

Diana Mota Toro, Pedro V. da Silva‐Neto, Jonatan C. S. de Carvalho, Carlos Alessandro Fuzo, Malena M. Pérez, Vinícius E. Pimentel, Thais Fernanda de Campos Fraga‐Silva, Camilla N. S. Oliveira, Glaucia Rigotto Caruso, Adriana Ferreira Lopes Vilela, Pedro Nobre-Azevedo, Thiago V. Defelippo-Felippe, Jamille Guedes Malta Argolo, Augusto M. Degiovani, Fátima M. Ostini, Marley Ribeiro Feitosa, Rogério Serafim Parra, Fernando Crivelenti Vilar, Gilberto Gambero Gaspar, José Joaquim Ribeiro da Rocha, Omar Féres, Gabriel Peinado Costa, Sandra Regina Maruyama, Elisa Maria de Sousa Russo, Ana Paula Fernandes, Isabel Kinney Ferreira de Miranda Santos, Adriana Malheiro, Ruxana T. Sadikot, Vânia Luiza Deperon Bonato, Cristina Ribeiro de Barros Cardoso, Marcelo Dias‐Baruffi, Átila Alexandre Trapé, Lúcia Helena Faccioli, Carlos A. Sorgi,

Pharmacological Receptor Mechanisms and Effects

SARS-CoV-2 infection triggers distinct patterns of disease development characterized by significant alterations in host regulatory responses. Severe cases exhibit profound lung inflammation and systemic repercussions. Remarkably, critically ill patients display a "lipid storm", influencing the inflammatory process and tissue damage. Sphingolipids (SLs) play pivotal roles in various cellular and tissue processes, including inflammation, metabolic disorders, and cancer. In this study, we employed high-resolution mass spectrometry to investigate SL metabolism in plasma samples obtained from control subjects (