Evaluation on Stability of Plant-Based Softgels (SeaGel® Technology) versus Gelatine Softgels
2023; University of Huddersfield Press; Volume: 8; Issue: 2 Linguagem: Inglês
10.5920/bjpharm.1397
ISSN2058-8356
AutoresMohammad Siddique Qadir, Jin Zhao, Becca Putans, Thomas Watson, Michael Evangelista, Ian B. Gillespie, J. A. Barnes,
Tópico(s)biodegradable polymer synthesis and properties
ResumoIn this study, a simple model fill formulation ofIbuprofen was encapsulated using either gelatine as the shell-forming materialor a plant-based material based on IFF’s SeaGel® technology (notedas SeaGel® softgels). The result indicates a similar performance at time zero betweenanimal-sourced material (gelatine) and plant-based material (SeaGel®).Importantly, at accelerated conditions, SeaGel® showed no change in performancein disintegration and dissolution over 6 months of stability compared to gelatinewhich showed significantly slower disintegration and dissolution behaviour thanfreshly produced gelatine softgels. This work indicates the superiorperformance of gelatine alternative SeaGel® softgels duringstability and long-term performance.
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