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Serotype-associated immune response and network immunoclusters in children and adults during acute Dengue virus infection

2023; Elsevier BV; Volume: 169; Linguagem: Inglês

10.1016/j.cyto.2023.156306

1096-0023

Pedro Henrique Ferreira Sucupira, Milene Silveira Ferreira, Mikelly Santos Coutinho-da-Silva, Kelly Alves Bicalho, Ana Carolina Campi‐Azevedo, Joaquim Pedro Brito‐de‐Sousa, Vanessa Peruhype-Magalhães, María Rios, Krishnamurthy Konduru, Andréa Teixeira−Carvalho, Jordana Grazziela Coelho-dos-Reis, Lis Ribeiro do Valle Antonelli, Vítor Bortolo de Rezende, Fernanda Ludolf Ribeiro de Melo, Cristiana C. Garcia, Jesuanne Carla Silva-Andrade, Ismael Artur da Costa-Rocha, Lucia Alves da Rocha, Valderjane Aprigio Silva, Sérgio Damasceno Pinto, Sabrina Araújo de Melo, Allyson Guimarães Costa, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Pedro Luiz Lima Bertarini, Erilene Cristina da Silva Furtado, Eliana Vieira Pinto da Silva, Bruna Alves Ramos, Éder Barros dos Santos, Maria Nazaré Oliveira Freitas, Ana Maria Caetano Faria, Pedro Fernando da Costa Vasconcelos, Michele de Souza Bastos, Livia Carício Martins, Olindo Assis Martins‐Filho, Márcio Sobreira Silva Araújo,

Dengue and Mosquito Control Research

The present study was designed as an exploratory investigation to characterize the overall profile of chemokines, growth factors, and pro-inflammatory/regulatory cytokines during acute DENV infection according to DENV-1, DENV-2, DENV-4 serotypes and age: children: 3x), except PDGF in which no fold change was observed. Moreover, despite the age ranges, DENV-1 and DENV-4 presented increased levels of VEGF, IL-6, and TNF-α in serum but decreased levels of PDGF, while DENV-2 exhibited increased levels of CXCL8, CCL4, and IL-12. Noteworthy was that DENV-2 showed increased levels of IL-12, IL-15, IL-17, IL-4, IL-9, and IL-13, and maintained an unaltered levels of PDGF at younger ages (<1–10 yo and 11–20 yo), whereas in older ages (21–40 yo and 41–75 yo), the results showed increased levels of CCL2, IL-6, and TNF-α, but lower levels of PDGF. In general, DENV infection at younger age groups exhibited more complex network immunoclusters as compared to older age groups. Multivariate analysis revealed a clustering of DENV cases according to age for a set of soluble mediators especially in subjects infected with DENV-2 serotype. Altogether, our findings demonstrate that the profile of circulating soluble mediators differs substantially in acute DENV according to age and DENV serotypes suggesting the participation of serotype-associated immune response, which may represent a potential target for development of therapeutics and could be used to assist medical directive for precise clinical management of severe cases.