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Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis

2023; Elsevier BV; Volume: 30; Issue: 8 Linguagem: Inglês

10.1016/j.stem.2023.07.002

1934-5909

Zhengyu Jiang, Feijing Wu, Pasquale Laise, Takayuki Tanaka, Na Fu, Woosook Kim, Hiroki Kobayashi, Wenju Chang, Ryota Takahashi, Giovanni Valenti, Masaki Sunagawa, Ruth A. White, Marina Macchini, Bernhard W. Renz, Moritz Middelhoff, Yoku Hayakawa, Zinaida A. Dubeykovskaya, Xiangtian Tan, Timothy Chu, Karan Nagar, Yagnesh Tailor, Bryana Belin, Akanksha Anand, Samuel Asfaha, Michael O. Finlayson, Alina C. Iuga, Andrea Califano, Timothy C. Wang,

Phagocytosis and Immune Regulation

While adult pancreatic stem cells are thought not to exist, it is now appreciated that the acinar compartment harbors progenitors, including tissue-repairing facultative progenitors (FPs). Here, we study a pancreatic acinar population marked by trefoil factor 2 (Tff2) expression. Long-term lineage tracing and single-cell RNA sequencing (scRNA-seq) analysis of Tff2-DTR-CreER