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Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds’ medicinal and edible flowers (Tagetes erecta L.)

2023; Brazilian Academy of Sciences; Volume: 95; Issue: suppl 1 Linguagem: Inglês

10.1590/0001-3765202320220427

1678-2690

Mariane Meurer, FABIULA FELISBINO, FABIANA B. MÜLLER, Líncon Bordignon Somensi, Benhur Judah Cury, Daniele Teixeira Jerônimo, Larissa Venzon, Tauani Caroline Santos França, Marihá Mariott, Ana Lúcia Castro da Silva Santos, Ruan Kaio Silva Nunes, Thaise Boeing, Alexandre Bella Cruz, Priscila de Souza, Walter Antônio Roman, Karuppusamy Arunachalam, Ruberlei Godinho de Oliveira, Luísa Mota da Silva,

Genomics, phytochemicals, and oxidative stress

The antiulcer mechanisms of the dry extract of T. erecta flowers (DETe) were studied here. The acute ulcers induced by acidified ethanol or indomethacin were reproduced in mice pretreated with DETe (3 - 300 mg/kg). The antiulcer activity of DETe was also verified in mice pretreated with NEM, L-NAME, indomethacin, or yohimbine. The antisecretory effect of DETe was verified in rats, and its anti-Helicobacter pylori activity was determined in vitro. DETe (300 mg/kg, p.o) reduced the ethanol- or indomethacin-induced ulcer by 49 and 93%, respectively. The pre-treatment with L-NAME, NEM or yohimbine abolished the gastroprotective effect of DETe. However, DETe did not change the volume, acidity, or peptic activity in rats and did not affect H. pylori. This study expands knowledge about the antiulcerogenic potential of DETe, evidencing the role of nitric oxide, non-protein sulfhydryl groups, α2 adrenergic receptors, and prostaglandins, but not antisecretory or anti-H. pylori properties.