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Associations Between Coronary Artery Calcification and Left Ventricular Global Longitudinal Strain and Diastolic Parameters: the ELSA-Brasil Study

2023; Elsevier BV; Volume: 204; Linguagem: Inglês

10.1016/j.amjcard.2023.06.124

1879-1913

Priscila Haas, Ângela Barreto Santiago Santos, Wilson Cañón-Montañéz, Márcio Sommer Bittencourt, Felipe Soares Torres, Antônio Luiz Pinho Ribeiro, Bruce Bartholow Duncan, Murilo Foppa,

Cardiac Valve Diseases and Treatments

Atherosclerosis burden can be evaluated in asymptomatic patients by measuring coronary artery calcification (CAC), whereas the global longitudinal strain (GLS) and diastolic function parameters (mitral E/e’ ratio, septal e′, and lateral e′) are used to evaluate subclinical left ventricular (LV) dysfunction. We investigated whether subjects with CAC (CAC >0 Agatston units) would present with an impairment in LV functional parameters. Among the participants of the ELSA-Brasil cohort free of clinically prevalent cardiovascular disease who performed cardiac computed tomography and echocardiography within the study protocol, we tested whether those with CAC >0 presented with worse GLS and diastolic function parameters. CAC >0 was present in 203 of the 612 included participants (33.17%; age 51.4 ± 8.6 years, 52.1% women). Absolute CAC values did not correlate with GLS (ro = 0.07, p = 0.105) but did so with E/e′ (ro = 0.19, p <0.001), septal e′ (ro = 0.28, p <0.001), and lateral e′ (ro = 0.30, p 0 had worse mitral E/e’ ratios (7.75 ± 0.13 vs 7.01 ± 0.09; p ≤0.001), septal e′ (8.25 ± 0.15 vs 9.59 ± 0.11 cm/s; p 0 with mitral E/e’ ratio and septal e’ in men. There is an association between subclinical coronary atherosclerosis and impaired LV functional parameters. These associations are more likely attributed to the presence of common cardiovascular risk factors in the general population. However, in men, it seems to exist as an independent association. Atherosclerosis burden can be evaluated in asymptomatic patients by measuring coronary artery calcification (CAC), whereas the global longitudinal strain (GLS) and diastolic function parameters (mitral E/e’ ratio, septal e′, and lateral e′) are used to evaluate subclinical left ventricular (LV) dysfunction. We investigated whether subjects with CAC (CAC >0 Agatston units) would present with an impairment in LV functional parameters. Among the participants of the ELSA-Brasil cohort free of clinically prevalent cardiovascular disease who performed cardiac computed tomography and echocardiography within the study protocol, we tested whether those with CAC >0 presented with worse GLS and diastolic function parameters. CAC >0 was present in 203 of the 612 included participants (33.17%; age 51.4 ± 8.6 years, 52.1% women). Absolute CAC values did not correlate with GLS (ro = 0.07, p = 0.105) but did so with E/e′ (ro = 0.19, p <0.001), septal e′ (ro = 0.28, p <0.001), and lateral e′ (ro = 0.30, p 0 had worse mitral E/e’ ratios (7.75 ± 0.13 vs 7.01 ± 0.09; p ≤0.001), septal e′ (8.25 ± 0.15 vs 9.59 ± 0.11 cm/s; p 0 with mitral E/e’ ratio and septal e’ in men. There is an association between subclinical coronary atherosclerosis and impaired LV functional parameters. These associations are more likely attributed to the presence of common cardiovascular risk factors in the general population. However, in men, it seems to exist as an independent association.