Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms
2023; Elsevier BV; Volume: 23; Issue: 7 Linguagem: Inglês
10.1016/j.pan.2023.08.002
ISSN1424-3911
AutoresLaura D. Wood, Volkan Adsay, Olca Baştürk, Lodewijk A.A. Brosens, Noriyoshi Fukushima, Seung‐Mo Hong, Sung Joo Kim, Jae W. Lee, Claudio Luchini, Michaël Noë, Martha B. Pitman, Aldo Scarpa, Aatur D. Singhi, Mariko Tanaka, Toru Furukawa,
Tópico(s)Cholangiocarcinoma and Gallbladder Cancer Studies
ResumoIntraductal papillary mucinous neoplasms (IPMNs) are a cystic precursor to pancreatic cancer. IPMNs deemed clinically to be at high-risk for malignant progression are frequently treated with surgical resection, and pathological examination of the pancreatectomy specimen is a key component of the clinical care of IPMN patients. Systematic literature reviews were conducted around eight topics of clinical relevance in the examination of pathological specimens in patients undergoing resection of IPMN. This review provides updated perspectives on morphological subtyping of IPMNs, classification of intraductal oncocytic papillary neoplasms, nomenclature for high-grade dysplasia, assessment of T stage, distinction of carcinoma associated or concomitant with IPMN, role of molecular assessment of IPMN tissue, role of intraoperative assessment by frozen section, and preoperative evaluation of cyst fluid cytology. This analysis provides the foundation for data-driven approaches to several challenging issues in the pathology of IPMNs.
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