Impaired health-related quality of life in the HCV cure era: who is concerned? (ANRS CO22 HEPATHER French cohort)
2023; Springer Science+Business Media; Volume: 32; Issue: 12 Linguagem: Inglês
10.1007/s11136-023-03496-w
ISSN1573-2649
AutoresPatrizia Carrieri, Marc Bourlière, Vincent Di Beo, Clovis Lusivika‐Nzinga, Clémence Ramier, Saskia Antwerpes, Camélia Protopopescu, Jean‐Marc Lacombe, Stanislas Pol, Hélène Fontaine, Abbas Mourad, Fabrice Carrat, Martin Duracinský, Fabienne Marcellin, Laurent Alric, Delphine Bonnet, Océane Camou, Fabien Zoulim, Marianne Maynard, François Bailly, Bénédicte Poumaroux, Miroslava Subic, F. Raffi, Éric Billaud, D. Boutoille, Maeva Lefebvre, Elisabeth André‐Garnier, Paul Calès, I. Hubert, Clémence M. Canivet, F. Lunel, Jérôme Boursier, Tarik Asselah, Nathalie Boyer, Nathalie Giuily, Corinne Castelnau, Giovanna Scoazec, Stanislas Pol, Hélène Fontaine, Lucia Parlati, Emilie Rousseaud, Anaı̈s Vallet-Pichard, Philippe Sogni, Victor de Lédinghen, Juliette Foucher, Jean‐Baptiste Hiriart, Paul Hermabessière, Marie Irlès-Depé, Marc Bourlière, Si Nafa Si Ahmed, Valérie Oulès, Rania Kibeche, Albert Tran, Rodolphe Anty, Ève Gelsi, Régine Truchi, Dominique Thabut, Saloua Hammeche, Joseph Moussali, Xavier Causse, Barbara De Dieuleveult, Brahim Ouarani, Damien Labarrière, Magali Jeulin, Nathalie Ganne‐Carrié, Véronique Grando–Lemaire, Pierre Nahon, Séverine Brulé, Lucie Del Pozo, Caroline Jézéquel, Audrey Brener, François Habersetzer, Thomas F. Baumert, Lawrence Serfaty, Pauline Simo‐Noumbissie, Alexandre Bolle, Jean‐Pierre Bronowicki, Mouni Bensenane-Oussalah, Vincent Haghnejad, Sébastien Daude, Sarah Hadj-Rhouma, Georges‐Philippe Pageaux, Dominique Larrey, M Mészáros, Sophie Métivier, Christophe Bureau, Thibault Morales, Jean Marie Péron, Hélène Larrue, Thomas Decaens, Marie‐Noëlle Hilleret, Charlotte Costentin, Bleuenn Brusset, Agnès Bonadona, Ghassan Riachi, Odile Goria, Fatima Paris, Hélène Montialoux, Vincent Leroy, Giuliana Amaddeo, Anne Varaut, Mélanie Simoes, Rachida Amzal, Slim Fourati, Olivier Chazouillières, Tony Andréani, Bénédicte Angoulevant, Azeline Chevance, Jean‐Charles Duclos Vallée, Audrey Coilly, Rodolphe Sobesky, Alina Pascale, Benjamin Buchard, Armand Abergel, Maud Reymond, Chanteranne Brigitte, Léon Muti, Vincent Di Martino, Claire Geist, Guillaume Conroy, Raphaëlle Riffault, Isabelle Rosa, Camille Barrault, Laurent Costes, Anne Wampach, V. Loustaud‐Ratti, Paul Carrier, Maryline Debette‐Gratien, Christine Silvain, Valentin Rolle, Valérie Roumy, Astrid Guyot d’Asnières de Salins, Philippe Mathurin, Guillaume Lassailly, Elise Lemaître, V. Canva, Sébastien Dharancy, Alexandre Louvet, Anne Minello, Marianne Latournerie, Thomas Mouillot Léa Lerosey, Théophile Gerster, Dominique Roulot, Zahia Ben Abdesselam, Louis d’Altéroche, C. Fleurent, Charlotte Nicolas, Laure Elkrief, Anaïs Jaillais, Denis Ouzan, Jérôme Gournay, Caroline Chevalier, Isabelle Archambeaud, Isabelle Portal, T. Dao, Moana Gelu‐Siméon, Marie-Josée Lafrance, Lucie Catherine, Fabrice Carrat, Frédéric Chau, Céline Dorival, Isabelle Goderel, Clovis Lusivika‐Nzinga, Jonathan Bellet, Jessica Chane-Teng, Grégory Pannetier, Jérôme Nicol, Carole Cagnot, Anaïs Boston, Laura Nailler, Guillaume Le Meut, Cécile Moins, Elise Landry, Alpha Diallo, Ventzislava Petrov–Sanchez, Marc Bourlière, Jérôme Boursier, Fabrice Carrat, Patrizia Carrieri, Elisabeth Delarocque‐Astagneau, Victor De Ledinghen, Céline Dorival, Hélène Fontaine, Slim Fourati, Chantal Housset, Dominique Larrey, Pierre Nahon, Georges‐Philippe Pageaux, Ventzislava Petrov–Sanchez, Stanislas Pol, Mathias Bruyand, Linda Wittkop, Fabien Zoulim, Jessica Zucman‐Rossi, Cécile Brouard, Frédéric Chau, Isabelle Goderel, Clovis Lusivika‐Nzinga, Jonathan Bellet, Jessica Chane-Teng, Grégory Pannetier, Jérôme Nicol, Marianne L’hennaff, Michèle Sizorn, Anaïs Boston, Alpha Diallo, Carole Cagnot, Alice Bousselet, Mireille Caralp,
Tópico(s)Liver Disease and Transplantation
ResumoHepatitis C virus (HCV) cure after treatment with direct-acting antivirals (DAAs) can improve health-related quality of life (HRQoL). However, specific groups with chronic HCV may still exhibit worse post-cure HRQoL because of persisting severe liver fibrosis or social vulnerability factors (e.g. unhealthy alcohol use, living in poverty). We assessed the effect of such factors on longitudinal measures of HRQoL in chronic HCV patients.ANRS CO22 HEPATHER is a prospective cohort of chronic HCV patients receiving DAAs, which included notably patients with social vulnerability factors, a population usually under-represented in clinical trials. Multivariable mixed-effects linear regression models helped identify factors associated with longitudinal measures of HRQoL (PROQOL-HCV scores).At enrolment, 52.4% of the 2740 participants were men, median age was 56 years [interquartile range 50-64], and 21.5% had severe liver fibrosis (FIB-4 > 3.25). Twenty-eight per cent reported current or past unhealthy alcohol use [> 2(3) alcohol units per day for women (men)], and 28.1% were living in poverty (standard of living under 1015€/month per household consumption unit). At first PROQOL-HCV completion, 54.0% of patients were HCV-cured. After multivariable adjustment, people with current or past unhealthy alcohol use, individuals living in poverty, those with severe liver fibrosis, and women had worse HRQoL in the dimensions explored. Conversely, HCV cure was associated with better HRQoL.Specific socially vulnerable groups of patients with chronic HCV infection still experience impaired HRQoL, independently of HCV cure. Patient-centred interventions, including social support and referral for comorbidities, should be prioritized for them. Trial registration with ClinicalTrials.gov NCT01953458.
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