Produção Nacional
Revisado por pares
Development of thymol nanoemulsions with potential application in oral infections
2023; Elsevier BV; Volume: 87; Linguagem: Inglês
10.1016/j.jddst.2023.104855
ISSN2588-8943
AutoresRodrigo Henrique Saatkamp, Mariele Paludetto Sanches, João Pedro Dornelles Gambin, Beatriz Ribeiro Amaral, Natália Silva de Farias, Thiago Caon, Carmen Maria Olivera Müller, Alexandre Luís Parize,
Tópico(s)Inhalation and Respiratory Drug Delivery
ResumoNanoemulsions (NEs) have been widely used for the incorporation of compounds that present low aqueous solubility, particularly due to high biocompatibility or improved efficacy. In this study, thymol, a known antimicrobial monoterpene, was incorporated into NEs through the spontaneous emulsification method (encapsulation efficiency> 95%) for application in oral infections. A particle size close to 200 nm was obtained, which increased with the amount of thymol. No changes in particle size, PDI and surface charge were found after storage for 45 days at 4 °C. The presence of thymol improved the NE stability, particularly at lower pH values (2 and 3), which was associated with interactions between thymol and phosphatidylcholine (confirmed by thermal analysis). In vitro release assays showed an initial burst effect followed by a sustained release. After 50 h, 81 and 58% of the initial total amount of thymol was released in water and saliva buffer, respectively. In buccal permeability studies, NEs contributed to improving the local distribution of the thymol in the oral cavity compared to the drug solution. All tested NEs (even systems without thymol) showed significant free-radical scavenging activity, which can reduce the tissue damage caused by oral infections. A concentration-dependent effect was observed as thymol was released from the NEs. Taken together, thymol-loaded NEs can be considered promising for treating oral infections.
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