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Retinal Optical Coherence Tomography Features Associated With Incident and Prevalent Parkinson Disease

2023; Lippincott Williams & Wilkins; Volume: 101; Issue: 16 Linguagem: Inglês

10.1212/wnl.0000000000207727

1526-632X

Siegfried Wagner, David Romero-Bascones, Mario Cortina‐Borja, Dominic J. Williamson, Robbert Struyven, Yukun Zhou, Salil Patel, Rimona S. Weil, Chrystalina A. Antoniades, Eric J. Topol, Edward Korot, Paul J. Foster, Konstantinos Balaskas, Unai Ayala, Maitane Barrenechea, Iñigo Gabilondo, Anthony H.V. Schapira, Anthony P. Khawaja, Praveen J. Patel, Jugnoo S. Rahi, Alastair K. Denniston, Axel Petzold, Pearse A. Keane, Naomi E. Allen, Tariq Aslam, Denize Atan, Sarah Barman, Jennifer H. Barrett, Paul N. Bishop, Graeme Black, Tasanee Braithwaite, Roxana O. Carare, Usha Chakravarthy, Michelle Chan, Sharon Chua, Alexander Day, Parul Desai, Bal Dhillon, Andrew D. Dick, Alex S. F. Doney, Cathy Egan, Sarah Ennis, Marcus Fruttiger, John EJ Gallacher, David F. Garway‐Heath, Jane Whitney Gibson, Jeremy A. Guggeinheim, Christopher J. Hammond, Alison J. Hardcastle, Simon Harding, Ruth Hogg, Pirro G. Hysi, Peng T. Khaw, Gerassimos Lascaratos, Thomas J. Littlejohns, Andrew Lotery, Robert Luben, Philip J. Luthert, Tom MacGillivray, Sarah Mackie, Bernadette McGuiness, Gareth J. McKay, Marin McKibbin, Tony Moore, James P. Morgan, Eoin O’Sullivan, Richard A. Oram, Christopher G. Owen, Euan Paterson, Tünde Pető, Alicja R. Rudnicka, Naveed Sattar, Jay Self, Panagiotis I. Sergouniotis, Sobha Sivaprasad, David Steel, Irene Stratton, Nicholas G. Strouthidis, Cathie Sudlow, Zihan Sun, Robyn J. Tapp, Dhanes Thomas, Emanuele Trucco, Adnan Tufail, Véronique Vitart, Ananth C. Viswanathan, Michael N. Weedon, Cathy Williams, Katie Williams, Jayne V. Woodside, MaxM. Yates, Jennifer Yip, Yalin Zheng,

Retinal Diseases and Treatments

Cadaveric studies have shown disease-related neurodegeneration and other morphological abnormalities in the retina of individuals with Parkinson disease (PD); however, it remains unclear whether this can be reliably detected with in vivo imaging. We investigated inner retinal anatomy, measured using optical coherence tomography (OCT), in prevalent PD and subsequently assessed the association of these markers with the development of PD using a prospective research cohort.