Cobalt-Catalyzed Aerobic Aminocyclization of Unsaturated Amides for the Synthesis of Functionalized γ- and δ-Lactams
2023; American Chemical Society; Volume: 25; Issue: 34 Linguagem: Inglês
10.1021/acs.orglett.3c02390
ISSN1523-7060
AutoresManuel Freis, Moritz Balkenhohl, David M. Fischer, Tony Georgiev, Roman C. Sarott, Erick M. Carreira,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoWe report the cobalt-catalyzed aminocyclization of unsaturated N-acyl sulfonamides in the presence of oxygen to provide γ- and δ-lactam aldehydes. Use of an optically active cobalt catalyst resulted in the formation of enantiomerically enriched γ-and δ-lactam alcohols. The γ-lactam aldehydes and alcohols obtained were elaborated into useful building blocks.
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