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Venetoclax, alone and in combination with the BH3 mimetic S63845, depletes HIV-1 latently infected cells and delays rebound in humanized mice

2023; Elsevier BV; Volume: 4; Issue: 9 Linguagem: Inglês

10.1016/j.xcrm.2023.101178

2666-3791

Philip Arandjelovic, Youry Kim, James P. Cooney, Simon Preston, Marcel Doerflinger, James McMahon, Sarah Garner, Jennifer M. Zerbato, Michael Roche, Carolin Tumpach, Jesslyn Ong, Dylan Sheerin, Gordon K. Smyth, Jenny L. Anderson, Cody Allison, Sharon R. Lewin, Marc Pellegrini,

Immune Cell Function and Interaction

HIV-1 persists indefinitely in people living with HIV (PLWH) on antiretroviral therapy (ART). If ART is stopped, the virus rapidly rebounds from long-lived latently infected cells. Using a humanized mouse model of HIV-1 infection and CD4