Produção Nacional
Revisado por pares
Genomic epidemiology unveils the dynamics and spatial corridor behind the Yellow Fever virus outbreak in Southern Brazil
2023; American Association for the Advancement of Science; Volume: 9; Issue: 35 Linguagem: Inglês
10.1126/sciadv.adg9204
ISSN2375-2548
AutoresMarta Giovanetti, Francesco Pinotti, Camila Zanluca, Vagner Fonseca, Taishi Nakase, Andrea Cristine Koishi, Marcel Kruchelski Tschá, Guilherme Marques Soares, Gisiane Gruber Dorl, Antônio Ernesto Meister Luz Marques, Renato Silva de Sousa, Talita Adelino, Joilson Xavier, Carla de Oliveira, Sandro Patroca, Natália Rocha Guimarães, Hegger Fritsch, Maria Angélica Mares-Guia, Flávia Mauad Levy, Pedro Henrique de Oliveira Passos, Vinicius Leme da Silva, Luiz Augusto Pereira, Ana Flávia Mendonça, Isabel Luana de Macêdo, Davi Emanuel Ribeiro de Sousa, Gabriela Rodrigues de Toledo Costa, Márcio Botelho de Castro, Miguel de Souza Andrade, Filipe Vieira Santos de Abreu, Fabrício Souza Campos, Felipe Campos de Melo Iani, Maira Alves Pereira, Karina Ribeiro Leite Jardim Cavalcante, André Ricardo Ribas Freitas, Carlos F. Campelo de Albuquerque, Eduardo Marques Macário, Marlei Pickler Debiasi dos Anjos, Rosane Campanher Ramos, Aline Alves Scarpellini Campos, Adriano Pintér, Márcia Chame, Lívia Abdalla, Irina Nastassja Riediger, Sérvio Pontes Ribeiro, Ana I. Bento, Túlio de Oliveira, Carla Freitas, Noely Fabiana Oliveira de Moura, Allison Fabri, Cintia Damasceno dos Santos Rodrigues, Carolina Cardoso dos Santos, Marco Antônio Barreto de Almeida, Edmilson dos Santos, Jáder da Cruz Cardoso, Douglas A. Augusto, Eduardo Krempser, Luís Filipe Mucci, R. Gatti, Sabrina Fernandes Cardoso, João Augusto Brancher Fuck, Maria Goretti David Lopes, Ivana Lúcia Belmonte, Gabriela Mayoral Pedroso da Silva, Maiane Regina Ferreira Soares, Marilia de Melo Santos de Castilhos, Joseana Cardoso de Souza e Silva, Alceu Bisetto, Emanuelle Gemin Pouzato, Laurina Setsuko Tanabe, Daniele Akemi Arita, Ricardo Matsuo, Josiane dos Santos Raymundo, Paula Cristina Linder Silva, Ana Santana Araújo Ferreira Silva, Sandra Samila, Glauco Carvalho, Rodrigo G. Stábeli, Wildo Navegantes, Luciano Andrade Moreira, Álvaro Ferreira, Guilherme Garcia Pinheiro, Bruno Tardelli Diniz Nunes, Daniele Barbosa de Almeida Medeiros, Ana Cecília Ribeiro Cruz, Rivaldo Venâncio da Cunha, Wesley C. Van Voorhis, Ana María Bispo de Filippis, María Almirón, Edward C. Holmes, Daniel Ramos, Alessandro Romano, José Lourenço, Luíz Carlos Júnior Alcântara, Claudia Nunes Duarte dos Santos,
Tópico(s)Primate Behavior and Ecology
ResumoDespite the considerable morbidity and mortality of yellow fever virus (YFV) infections in Brazil, our understanding of disease outbreaks is hampered by limited viral genomic data. Here, through a combination of phylogenetic and epidemiological models, we reconstructed the recent transmission history of YFV within different epidemic seasons in Brazil. A suitability index based on the highly domesticated Aedes aegypti was able to capture the seasonality of reported human infections. Spatial modeling revealed spatial hotspots with both past reporting and low vaccination coverage, which coincided with many of the largest urban centers in the Southeast. Phylodynamic analysis unraveled the circulation of three distinct lineages and provided proof of the directionality of a known spatial corridor that connects the endemic North with the extra-Amazonian basin. This study illustrates that genomics linked with eco-epidemiology can provide new insights into the landscape of YFV transmission, augmenting traditional approaches to infectious disease surveillance and control.
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