Integrating ion mobility and imaging mass spectrometry for comprehensive analysis of biological tissues: A brief review and perspective
2020; Wiley; Volume: 55; Issue: 12 Linguagem: Inglês
10.1002/jms.4421
ISSN1096-9888
AutoresEmilio Rivera, Katerina Djambazova, Elizabeth K. Neumann, Richard M. Caprioli, Jeffrey M. Spraggins,
Tópico(s)Metabolomics and Mass Spectrometry Studies
ResumoJournal of Mass SpectrometryVolume 55, Issue 12 e4421 p. ii-ii COVER STORYFree Access Integrating ion mobility and imaging mass spectrometry for comprehensive analysis of biological tissues: A brief review and perspective Emilio S. Rivera, Emilio S. RiveraSearch for more papers by this authorKaterina V. Djambazova, Katerina V. DjambazovaSearch for more papers by this authorElizabeth K. Neumann, Elizabeth K. NeumannSearch for more papers by this authorRichard M. Caprioli, Richard M. CaprioliSearch for more papers by this authorJeffrey M. Spraggins, Jeffrey M. SpragginsSearch for more papers by this author Emilio S. Rivera, Emilio S. RiveraSearch for more papers by this authorKaterina V. Djambazova, Katerina V. DjambazovaSearch for more papers by this authorElizabeth K. Neumann, Elizabeth K. NeumannSearch for more papers by this authorRichard M. Caprioli, Richard M. CaprioliSearch for more papers by this authorJeffrey M. Spraggins, Jeffrey M. SpragginsSearch for more papers by this author First published: 08 December 2020 https://doi.org/10.1002/jms.4421AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract The ion separation capability of ion mobility has major advantages when coupled to mass spectrometry to significantly simplify spectral complexity. Moreover, use of ion mobility for discrimination of ions with similar or equal m/z is invaluable for direct tissue analysis where MS instruments cannot distinguish structural isomers using mass resolving power alone. Ion mobility has been integrated with imaging MS (IMS), providing efficient ion separation prior to mass analysis and providing increased signal-to-noise. As the resolving power of ion mobility technologies continues to improve, applications of ion mobility-IMS to discriminate biomolecules closer in m/z without the need for ultra-high mass resolving power mass spectrometers will be of significant benefit. In this perspective special feature article, the authors briefly describe recent advances in the field of ion mobility-IMS. They also discuss how recent advances impact the current state of the ion mobility-IMS field as well as implications for the future. Jeffrey Spraggins is a Research Assistant Professor in the Department of Biochemistry and is a member of the Mass Spectrometry Research Center (MSRC) at Vanderbilt University School of Medicine. Richard Caprioli is Professor in Biochemistry and Director of the MSRC. Their research is focused on developing new mass spectrometric technologies to enhance biomolecular imaging experiments. Volume55, Issue12December 2020Pages ii-ii RelatedInformation
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