Synthesis and Biological Studies of Benzo[b]furan Derivatives: A Review from 2011 to 2022
2023; Multidisciplinary Digital Publishing Institute; Volume: 16; Issue: 9 Linguagem: Inglês
10.3390/ph16091265
ISSN1424-8247
AutoresLizeth Arce-Ramos, Juan‐Carlos Castillo, Diana Becerra,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoThe importance of the benzo[b]furan motif becomes evident in the remarkable results of numerous biological investigations, establishing its potential as a robust therapeutic option. This review presents an overview of the synthesis of and exhaustive biological studies conducted on benzo[b]furan derivatives from 2011 to 2022, accentuating their exceptional promise as anticancer, antibacterial, and antifungal agents. Initially, the discussion focuses on chemical synthesis, molecular docking simulations, and both in vitro and in vivo studies. Additionally, we provide an analysis of the intricate interplay between structure and activity, thereby facilitating comparisons and profoundly emphasizing the applications of the benzo[b]furan motif within the realms of drug discovery and medicinal chemistry.
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