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P22.01: Preliminary investigation of the utility of MRI for measuring the hematocrit in fetal anemia

2016; Wiley; Volume: 48; Issue: S1 Linguagem: Inglês

10.1002/uog.16708

1469-0705

Anqi Duan, Johannes Keunen, Sharon Portnoy, Meng Yuan Zhu, C. Anastasiadis, Greg Ryan, Prashob Porayette, Brahmdeep S. Saini, John G. Sled, Christopher K. Macgowan, Mike Seed,

Parvovirus B19 Infection Studies

The detection of fetal anemia by middle cerebral artery peak systolic velocity is less reliable with advancing gestational age (GA) and prior transfusion. We sought to investigate the feasibility and accuracy of a new MRI method for measuring fetal hematocrit (Hct) in vivo in anemic fetuses. We recruited 4 pregnant women suspected of carrying anemic fetuses between 19 and 38 weeks GA. Two fetuses had Rh alloimmunisation, one had alpha-thalassemia and two had twin anemia-polycythemia sequence. The fetuses underwent MRI scans either immediately before or after their intrauterine transfusions (IUT), or both. The scans were performed on a 1.5T Siemens scanner and included T1 and T2 mapping of the intrahepatic umbilical vein. We used vessel T1 and T2 to calculate Hct according to our previously published technique [Portnoy et al. ISMRM 2015]. MRI Hct was compared with the Hct from cordocentesis samples obtained during IUT. The Hct values we calculated from T1 and T2 times showed excellent agreement with the gold-standard laboratory Hct (see figure 1). The mean difference between the MRI-predicted Hct and the laboratory values is 3.7%. Our method was accurate for a wide range of fetal hematocrit, from anemia to polycythemia, and for both before and after IUT. Supporting information can be found in the online version of this abstract Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.