Produção Nacional
Revisado por pares
Causes and consequences of child growth faltering in low-resource settings
2023; Nature Portfolio; Volume: 621; Issue: 7979 Linguagem: Inglês
10.1038/s41586-023-06501-x
ISSN1476-4687
AutoresAndrew Mertens, Jade Benjamin‐Chung, John M. Colford, Jeremy Coyle, Mark J. van der Laan, Alan Hubbard, Sonali Rosete, Ivana Malenica, Nima S. Hejazi, Oleg Sofrygin, Weixin Cai, Haodong Li, Anna Nguyen, Nolan N. Pokpongkiat, Stephanie Djajadi, Anmol Seth, Esther Jung, Esther O. Chung, Wendy Jilek, Vishak Subramoney, Ryan Hafen, Jonas Häggström, Thea Norman, Kenneth H. Brown, Parul Christian, Benjamin F. Arnold, Souheila Abbeddou, Linda S. Adair, Tahmeed Ahmed, Asad Ali, Hasmot Ali, Per Ashorn, Rajiv Bahl, Maurício L. Barreto, Elodie Becquey, France Bégin, Pascal Bessong, Maharaj Kishan Bhan, Nita Bhandari, Santosh K. Bhargava, Zulfiqar A Bhutta, Robert E. Black, Ladaporn Bodhidatta, Delia B. Carba, William Checkley, Parul Christian, Jean E. Crabtree, Kathryn G. Dewey, Christopher Duggan, Caroline Fall, Abu Syed Golam Faruque, Wafaie Fawzi, José Quirino da Silva Filho, Robert H. Gilman, Richard L. Guerrant, Rashidul Haque, S. M. Tafsir Hasan, Sonja Y. Hess, Eric R. Houpt, Jean H. Humphrey, Najeeha Talat Iqbal, Elizabeth Yakes Jimenez, Jacob John, Sushil Matthew John, Gagandeep Kang, Margaret Kosek, Michael S. Kramer, Alain Labrique, Sang Lee, Aldo Â. M. Lima, Tjale Cloupas Mahopo, Kenneth Maleta, Dharma Manandhar, Karim Manji, Reynaldo Martorell, Sarmila Mazumder, Estomih Mduma, Venkata Raghava Mohan, Sophie E. Moore, Robert Ntozini, Mzwakhe Emanuel Nyathi, Maribel Paredes Olórtegui, Césaire T. Ouédraogo, William A. Petri, Prasanna Samuel Premkumar, Andrew M. Prentice, Najeeb Rahman, Manuel Ramírez‐Zea, Harshpal Singh Sachdev, Kamran Sadiq, Rajiv Sarkar, Monira Sarmin, Naomi Saville, Saijuddin Shaikh, Bhim P. Shrestha, Sanjaya K. Shrestha, Alberto M. Soares, Bakary Sonko, Aryeh D. Stein, Erling Svensen, Sana Syed, Fayaz Umrani, Honorine Ward, Keith P. West, Lee Wu, Seungmi Yang, Pablo Peñataro Yori,
Tópico(s)Global Maternal and Child Health
ResumoAbstract Growth faltering in children (low length for age or low weight for length) during the first 1,000 days of life (from conception to 2 years of age) influences short-term and long-term health and survival 1,2 . Interventions such as nutritional supplementation during pregnancy and the postnatal period could help prevent growth faltering, but programmatic action has been insufficient to eliminate the high burden of stunting and wasting in low- and middle-income countries. Identification of age windows and population subgroups on which to focus will benefit future preventive efforts. Here we use a population intervention effects analysis of 33 longitudinal cohorts (83,671 children, 662,763 measurements) and 30 separate exposures to show that improving maternal anthropometry and child condition at birth accounted for population increases in length-for-age z -scores of up to 0.40 and weight-for-length z -scores of up to 0.15 by 24 months of age. Boys had consistently higher risk of all forms of growth faltering than girls. Early postnatal growth faltering predisposed children to subsequent and persistent growth faltering. Children with multiple growth deficits exhibited higher mortality rates from birth to 2 years of age than children without growth deficits (hazard ratios 1.9 to 8.7). The importance of prenatal causes and severe consequences for children who experienced early growth faltering support a focus on pre-conception and pregnancy as a key opportunity for new preventive interventions.
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