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Characterizing the mutational burden, DNA methylation landscape, and proteome of germ cell tumor-related somatic-type malignancies to identify the tissue-of-origin, mechanisms of therapy resistance, and druggable targets

2023; Springer Nature; Volume: 129; Issue: 10 Linguagem: Inglês

10.1038/s41416-023-02425-5

1532-1827

Felix Bremmer, Pailin Pongratanakul, Margaretha A. Skowron, Yue Che, Annika Richter, Stefan Küffer, Kirsten Reuter‐Jessen, Hanibal Bohnenberger, Stella Pauls, Catena Kresbach, Ulrich Schüller, Kai Stühler, Philipp Ströbel, Peter Albers, Daniel Nettersheim,

Urologic and reproductive health conditions

Germ cell tumors (GCT) might undergo transformation into a somatic-type malignancy (STM), resulting in a cell fate switch to tumors usually found in somatic tissues, such as rhabdomyosarcomas or adenocarcinomas. STM is associated with a poor prognosis, but the molecular and epigenetic mechanisms triggering STM are still enigmatic, the tissue-of-origin is under debate and biomarkers are lacking.